Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 3982082..3982720 Replicon chromosome
Accession NZ_CP127306
Organism Escherichia coli strain C51

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag QRM70_RS19415 Protein ID WP_000813794.1
Coordinates 3982544..3982720 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QRM70_RS19410 Protein ID WP_001270286.1
Coordinates 3982082..3982498 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM70_RS19385 (3977399) 3977399..3978052 - 654 Protein_3754 ABC transporter ATP-binding protein -
QRM70_RS19395 (3978821) 3978821..3979189 - 369 Protein_3756 ABC transporter ATP-binding protein -
QRM70_RS19400 (3979207) 3979207..3980352 - 1146 WP_000047456.1 ABC transporter substrate-binding protein -
QRM70_RS19405 (3980597) 3980597..3982003 - 1407 WP_000760629.1 PLP-dependent aminotransferase family protein -
QRM70_RS19410 (3982082) 3982082..3982498 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QRM70_RS19415 (3982544) 3982544..3982720 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QRM70_RS19420 (3982942) 3982942..3983172 + 231 WP_000494244.1 YncJ family protein -
QRM70_RS19425 (3983264) 3983264..3985225 - 1962 WP_001307191.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QRM70_RS19430 (3985298) 3985298..3985834 - 537 WP_000429141.1 DNA-binding transcriptional regulator SutR -
QRM70_RS19435 (3985926) 3985926..3987101 + 1176 Protein_3764 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3987141..3988406 1265


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T284126 WP_000813794.1 NZ_CP127306:c3982720-3982544 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT284126 WP_001270286.1 NZ_CP127306:c3982498-3982082 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References