Detailed information of TA system TA028412

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1351346..1351940
• Replicon: chromosome
• Accession: NC_018828
• Organism: Bordetella parapertussis Bpp5

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: K0M8J0
• Locus tag: BN117_RS06335
• Protein ID: WP_010928352.1
• Coordinates: 1351758..1351940 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: K0MFV7
• Locus tag: BN117_RS06330
• Protein ID: WP_010928351.1
• Coordinates: 1351346..1351735 (-)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BN117_RS06305	1347189..1348229	+	1041	WP_003809635.1	phosphate ABC transporter substrate-binding protein PstS	-
BN117_RS06310	1348364..1349380	+	1017	WP_003809636.1	phosphate ABC transporter permease subunit PstC	-
BN117_RS06315	1349402..1350259	+	858	WP_003809638.1	phosphate ABC transporter permease PstA	-
BN117_RS06320	1350304..1351080	+	777	WP_164926475.1	phosphate ABC transporter ATP-binding protein PstB	-
BN117_RS06330	1351346..1351735	-	390	WP_010928351.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
BN117_RS06335	1351758..1351940	-	183	WP_010928352.1	type II toxin-antitoxin system HicA family toxin	Toxin
BN117_RS06340	1352348..1353046	+	699	WP_003809653.1	gluconate 2-dehydrogenase subunit 3 family protein	-
BN117_RS06345	1353050..1354819	+	1770	WP_010926160.1	GMC family oxidoreductase	-
BN117_RS06350	1354830..1356183	+	1354	Protein_1247	cytochrome c	-
BN117_RS06355	1356195..1356935	-	741	WP_015039240.1	carbonic anhydrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-122)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6750.76 Da
• Isoelectric Point: 11.4018

>T28412 WP_010928352.1 NC_018828:c1351940-1351758 [Bordetella parapertussis Bpp5]
MNSTDLIQQPKADGWYRVHTVGSHHQYKHPTKPGKVTVPHPRKGLPTATQRSILKQAGLR

Nucleotide

• Length: 183 bp

>T28412 NC_018828:c1351940-1351758 [Bordetella parapertussis Bpp5]
ATGAACAGCACAGACCTGATCCAGCAACCGAAGGCCGACGGCTGGTATCGCGTGCATACCGTGGGTTCACACCACCAGTA
CAAGCACCCGACCAAGCCCGGCAAGGTCACCGTGCCGCATCCCAGGAAGGGCCTGCCGACAGCGACACAGCGCAGCATCC
TTAAGCAAGCCGGCCTGCGATAA

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 14270.92 Da
• Isoelectric Point: 4.3014

>AT28412 WP_010928351.1 NC_018828:c1351735-1351346 [Bordetella parapertussis Bpp5]
MLYPIHVSKDEGSAYGAAFPDFPGCFAAADELQDLPRAAQEAVEAHFYGETERIPAPSAPEAWANDEDYQGGYWMMVDID
LSKVNTKAVRLNISLPENLVHRIDEEAKARRLSRSAFLAMAAEHEMADA

Nucleotide

• Length: 390 bp

>AT28412 NC_018828:c1351735-1351346 [Bordetella parapertussis Bpp5]
ATGCTCTACCCGATCCATGTTTCCAAAGACGAAGGCAGCGCCTACGGGGCCGCCTTCCCTGATTTTCCCGGCTGCTTTGC
AGCCGCCGATGAACTCCAGGACCTCCCCCGCGCGGCGCAGGAAGCCGTTGAGGCGCACTTCTACGGAGAGACCGAGCGTA
TCCCCGCCCCGTCCGCCCCTGAAGCGTGGGCCAACGATGAGGACTATCAAGGCGGCTATTGGATGATGGTCGATATCGAC
CTGTCGAAGGTCAACACGAAGGCCGTGCGGCTCAACATCAGCCTGCCGGAAAACCTGGTTCACCGTATCGACGAGGAAGC
CAAGGCACGACGCCTTTCGCGCTCAGCGTTTCTGGCCATGGCTGCGGAGCACGAAATGGCCGACGCCTAG

Structures

Toxin

• AlphaFold DB: K0M8J0

Antitoxin

• AlphaFold DB: K0MFV7