Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2871199..2871824 Replicon chromosome
Accession NZ_CP127306
Organism Escherichia coli strain C51

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QRM70_RS14030 Protein ID WP_000911330.1
Coordinates 2871426..2871824 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag QRM70_RS14025 Protein ID WP_000450524.1
Coordinates 2871199..2871426 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM70_RS14000 (2867002) 2867002..2867472 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
QRM70_RS14005 (2867472) 2867472..2868044 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
QRM70_RS14010 (2868190) 2868190..2869068 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
QRM70_RS14015 (2869085) 2869085..2870119 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
QRM70_RS14020 (2870332) 2870332..2871045 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
QRM70_RS14025 (2871199) 2871199..2871426 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
QRM70_RS14030 (2871426) 2871426..2871824 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
QRM70_RS14035 (2871971) 2871971..2872834 + 864 WP_001267508.1 neutral zinc metallopeptidase -
QRM70_RS14040 (2872849) 2872849..2874864 + 2016 WP_000829329.1 tRNA cytosine(34) acetyltransferase TmcA -
QRM70_RS14045 (2874938) 2874938..2875636 + 699 WP_000679823.1 esterase -
QRM70_RS14050 (2875746) 2875746..2875946 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T284118 WP_000911330.1 NZ_CP127306:2871426-2871824 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT284118 WP_000450524.1 NZ_CP127306:2871199-2871426 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References