284115

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2385296..2385950 Replicon chromosome
Accession NZ_CP127306
Organism Escherichia coli strain C51

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag QRM70_RS11610 Protein ID WP_000244772.1
Coordinates 2385543..2385950 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QRM70_RS11605 Protein ID WP_000354046.1
Coordinates 2385296..2385562 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM70_RS11580 (2380584) 2380584..2381327 + 744 WP_000951964.1 SDR family oxidoreductase -
QRM70_RS11585 (2381384) 2381384..2382817 - 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
QRM70_RS11590 (2382862) 2382862..2383173 + 312 WP_001182944.1 N(4)-acetylcytidine aminohydrolase -
QRM70_RS11595 (2383337) 2383337..2383996 + 660 WP_000250274.1 hemolysin III family protein -
QRM70_RS11600 (2384073) 2384073..2385053 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
QRM70_RS11605 (2385296) 2385296..2385562 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QRM70_RS11610 (2385543) 2385543..2385950 + 408 WP_000244772.1 protein YgfX Toxin
QRM70_RS11615 (2385990) 2385990..2386511 - 522 WP_001055874.1 flavodoxin FldB -
QRM70_RS11620 (2386623) 2386623..2387519 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QRM70_RS11625 (2387544) 2387544..2388254 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QRM70_RS11630 (2388260) 2388260..2389993 + 1734 WP_000813215.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T284115 WP_000244772.1 NZ_CP127306:2385543-2385950 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT284115 WP_000354046.1 NZ_CP127306:2385296-2385562 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References