Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1728508..1729094 Replicon chromosome
Accession NZ_CP127306
Organism Escherichia coli strain C51

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag QRM70_RS08275 Protein ID WP_042014162.1
Coordinates 1728508..1728738 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag QRM70_RS08280 Protein ID WP_000593555.1
Coordinates 1728735..1729094 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM70_RS08265 (1724545) 1724545..1727280 + 2736 WP_000149165.1 ribosome-associated ATPase/putative transporter RbbA -
QRM70_RS08270 (1727280) 1727280..1728404 + 1125 WP_001314210.1 ABC transporter permease -
QRM70_RS08275 (1728508) 1728508..1728738 + 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
QRM70_RS08280 (1728735) 1728735..1729094 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QRM70_RS08285 (1729214) 1729214..1729615 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
QRM70_RS08290 (1729621) 1729621..1730427 - 807 WP_000173666.1 nickel import ATP-binding protein NikE -
QRM70_RS08295 (1730424) 1730424..1731188 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
QRM70_RS08300 (1731188) 1731188..1732021 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
QRM70_RS08305 (1732018) 1732018..1732962 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T284111 WP_042014162.1 NZ_CP127306:1728508-1728738 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT284111 WP_000593555.1 NZ_CP127306:1728735-1729094 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References