Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 965947..966444 Replicon chromosome
Accession NZ_CP127306
Organism Escherichia coli strain C51

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QRM70_RS04770 Protein ID WP_001173343.1
Coordinates 965947..966120 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag QRM70_RS04775 Protein ID WP_000398619.1
Coordinates 966148..966444 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM70_RS04760 (962617) 962617..964074 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
QRM70_RS04765 (964311) 964311..965828 + 1518 WP_001295074.1 lysine--tRNA ligase -
QRM70_RS04770 (965947) 965947..966120 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QRM70_RS04775 (966148) 966148..966444 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QRM70_RS04780 (966671) 966671..966943 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
QRM70_RS04785 (966955) 966955..967185 - 231 WP_000371698.1 4Fe-4S mono-cluster protein YjdI -
QRM70_RS04790 (967366) 967366..968997 + 1632 WP_001216461.1 sensor histidine kinase -
QRM70_RS04795 (968994) 968994..969713 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T284109 WP_001173343.1 NZ_CP127306:c966120-965947 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT284109 WP_000398619.1 NZ_CP127306:c966444-966148 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References