284107

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 743862..744676 Replicon chromosome
Accession NZ_CP127306
Organism Escherichia coli strain C51

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag QRM70_RS03640 Protein ID WP_001054376.1
Coordinates 743862..744119 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag QRM70_RS03645 Protein ID WP_001309181.1
Coordinates 744131..744676 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM70_RS03615 (739150) 739150..740256 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
QRM70_RS03620 (740321) 740321..741301 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
QRM70_RS03625 (741411) 741411..741616 + 206 Protein_687 HNH endonuclease -
QRM70_RS03630 (741884) 741884..743124 - 1241 Protein_688 helicase YjhR -
QRM70_RS03635 (743240) 743240..743371 + 132 WP_001309182.1 hypothetical protein -
QRM70_RS03640 (743862) 743862..744119 + 258 WP_001054376.1 YjhX family toxin Toxin
QRM70_RS03645 (744131) 744131..744676 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
QRM70_RS03650 (744732) 744732..745437 + 706 Protein_692 class I SAM-dependent methyltransferase -
QRM70_RS03655 (745606) 745606..745824 + 219 Protein_693 hypothetical protein -
QRM70_RS03660 (745862) 745862..745978 + 117 Protein_694 VOC family protein -
QRM70_RS03665 (746223) 746223..747344 + 1122 WP_000010829.1 M42 family metallopeptidase -
QRM70_RS03670 (747341) 747341..747619 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
QRM70_RS03675 (747631) 747631..748944 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimC / fimI / fimA / fimE / fimB 733250..760325 27075


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T284107 WP_001054376.1 NZ_CP127306:743862-744119 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT284107 WP_001309181.1 NZ_CP127306:744131-744676 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References