284105

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 150795..151632 Replicon chromosome
Accession NZ_CP127306
Organism Escherichia coli strain C51

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag QRM70_RS00950 Protein ID WP_000227784.1
Coordinates 151090..151632 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag QRM70_RS00945 Protein ID WP_001297137.1
Coordinates 150795..151106 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM70_RS00920 (145815) 145815..146762 + 948 WP_021548571.1 cytochrome o ubiquinol oxidase subunit II -
QRM70_RS00925 (146784) 146784..148775 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
QRM70_RS00930 (148765) 148765..149379 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
QRM70_RS00935 (149379) 149379..149708 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
QRM70_RS00940 (149720) 149720..150610 + 891 WP_000971336.1 heme o synthase -
QRM70_RS00945 (150795) 150795..151106 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
QRM70_RS00950 (151090) 151090..151632 + 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
QRM70_RS00955 (151688) 151688..152623 - 936 WP_001297127.1 tetratricopeptide repeat protein -
QRM70_RS00960 (153031) 153031..154395 + 1365 WP_001000978.1 MFS transporter -
QRM70_RS00965 (154523) 154523..155014 - 492 WP_001138904.1 nucleotide binding protein YajQ -
QRM70_RS00970 (155182) 155182..156093 + 912 WP_000705847.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T284105 WP_000227784.1 NZ_CP127306:151090-151632 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT284105 WP_001297137.1 NZ_CP127306:150795-151106 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References