Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 116719..117337 Replicon chromosome
Accession NZ_CP127306
Organism Escherichia coli strain C51

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QRM70_RS00780 Protein ID WP_001291435.1
Coordinates 117119..117337 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QRM70_RS00775 Protein ID WP_000344800.1
Coordinates 116719..117093 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM70_RS00765 (111808) 111808..113001 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QRM70_RS00770 (113024) 113024..116173 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QRM70_RS00775 (116719) 116719..117093 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QRM70_RS00780 (117119) 117119..117337 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QRM70_RS00785 (117509) 117509..118060 + 552 WP_000102568.1 maltose O-acetyltransferase -
QRM70_RS00790 (118176) 118176..118646 + 471 WP_000136192.1 YlaC family protein -
QRM70_RS00795 (118810) 118810..120360 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QRM70_RS00800 (120402) 120402..120755 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QRM70_RS00810 (121134) 121134..121445 + 312 WP_000409911.1 MGMT family protein -
QRM70_RS00815 (121476) 121476..122048 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T284104 WP_001291435.1 NZ_CP127306:117119-117337 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT284104 WP_000344800.1 NZ_CP127306:116719-117093 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References