Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4825874..4826492 Replicon chromosome
Accession NZ_CP127303
Organism Escherichia coli strain APEC37

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QRM68_RS25030 Protein ID WP_001291435.1
Coordinates 4826274..4826492 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QRM68_RS25025 Protein ID WP_000344800.1
Coordinates 4825874..4826248 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM68_RS25015 (4820963) 4820963..4822156 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QRM68_RS25020 (4822179) 4822179..4825328 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QRM68_RS25025 (4825874) 4825874..4826248 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QRM68_RS25030 (4826274) 4826274..4826492 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QRM68_RS25035 (4826663) 4826663..4827214 + 552 WP_000102564.1 maltose O-acetyltransferase -
QRM68_RS25040 (4827329) 4827329..4827799 + 471 WP_000136192.1 YlaC family protein -
QRM68_RS25045 (4827963) 4827963..4829513 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QRM68_RS25050 (4829555) 4829555..4829908 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QRM68_RS25060 (4830287) 4830287..4830598 + 312 WP_000409911.1 MGMT family protein -
QRM68_RS25065 (4830629) 4830629..4831201 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T284103 WP_001291435.1 NZ_CP127303:4826274-4826492 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT284103 WP_000344800.1 NZ_CP127303:4825874-4826248 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References