Detailed information of TA system TA028410

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yafQ-relB/YafQ-DinJ
• Location: 751439..751964
• Replicon: chromosome
• Accession: NC_018720
• Organism: Bifidobacterium asteroides PRL2011

Toxin (Protein)

• Gene name: yafQ
• Uniprot ID: K4J095
• Locus tag: BAST_RS02835
• Protein ID: WP_015021574.1
• Coordinates: 751439..751717 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: K4IQ07
• Locus tag: BAST_RS02840
• Protein ID: WP_015021575.1
• Coordinates: 751710..751964 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BAST_RS02805	746718..747611	+	894	WP_015021569.1	FtsQ-type POTRA domain-containing protein	-
BAST_RS02810	747604..748104	-	501	WP_015021570.1	D-tyrosyl-tRNA(Tyr) deacylase	-
BAST_RS02815	748499..749017	-	519	WP_015021571.1	GNAT family N-acetyltransferase	-
BAST_RS02820	749086..749448	-	363	WP_099327376.1	multidrug efflux SMR transporter	-
BAST_RS02830	749679..751118	+	1440	WP_015021573.1	FtsX-like permease family protein	-
BAST_RS02835	751439..751717	-	279	WP_015021574.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
BAST_RS02840	751710..751964	-	255	WP_015021575.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
BAST_RS02845	752718..753689	-	972	WP_033510981.1	LysR family transcriptional regulator	-
BAST_RS02850	753892..755514	-	1623	WP_015021577.1	NAD-dependent malic enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-55)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 11273.06 Da
• Isoelectric Point: 10.3456

>T28410 WP_015021574.1 NC_018720:c751717-751439 [Bifidobacterium asteroides PRL2011]
MYKFAYTQKFLRDVKKIKRKHFDLSRLDQVLDDLADYNASLLKRKYRNHRLKGHWSKYEELHVDADWLLVYKRDKNRMIL
TLMTTGSHDQTL

Nucleotide

• Length: 279 bp

>T28410 NC_018720:c751717-751439 [Bifidobacterium asteroides PRL2011]
ATGTATAAGTTTGCATATACGCAAAAATTCCTGCGTGATGTCAAGAAAATCAAAAGGAAGCATTTCGACTTGAGCAGGCT
TGATCAGGTACTTGACGACTTGGCTGACTACAATGCATCACTGCTTAAACGAAAATACCGAAATCACCGATTGAAAGGAC
ACTGGTCTAAATACGAGGAGCTGCATGTCGACGCGGACTGGCTGCTCGTGTACAAGCGCGATAAGAATCGAATGATTCTT
ACCTTGATGACCACCGGGAGCCATGACCAAACACTGTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9561.82 Da
• Isoelectric Point: 5.1312

>AT28410 WP_015021575.1 NC_018720:c751964-751710 [Bifidobacterium asteroides PRL2011]
MKETARIQIRTSEDMKRRASQLFEDLGLDLGTAINMFLSQSLREGGLPFRSQLSKFDREMEEAEASPVTHAGDVENMKDI
IHHV

Nucleotide

• Length: 255 bp

>AT28410 NC_018720:c751964-751710 [Bifidobacterium asteroides PRL2011]
ATGAAAGAGACAGCGAGAATTCAAATTCGAACCAGCGAGGATATGAAGCGTCGAGCCTCACAGCTTTTCGAAGATTTAGG
CCTTGATCTCGGCACGGCTATTAACATGTTTCTCTCTCAGTCGCTGCGCGAAGGAGGACTTCCATTCCGCTCCCAACTTT
CCAAATTTGACAGGGAAATGGAGGAAGCCGAGGCTTCACCGGTCACTCACGCGGGTGATGTAGAGAACATGAAAGACATC
ATCCATCATGTATAA

Structures

Toxin

• AlphaFold DB: K4J095

Antitoxin

• AlphaFold DB: K4IQ07