Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 2090017..2090567 Replicon chromosome
Accession NZ_CP127303
Organism Escherichia coli strain APEC37

Toxin (Protein)


Gene name ccdB Uniprot ID D3H432
Locus tag QRM68_RS11630 Protein ID WP_001160975.1
Coordinates 2090253..2090567 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID D3H431
Locus tag QRM68_RS11625 Protein ID WP_000125565.1
Coordinates 2090017..2090250 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM68_RS11600 (2085088) 2085088..2085375 + 288 WP_000203741.1 ferredoxin-like protein FixX -
QRM68_RS11605 (2085433) 2085433..2086764 + 1332 WP_001183198.1 MFS transporter -
QRM68_RS11610 (2086875) 2086875..2087405 + 531 WP_000600718.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
QRM68_RS11615 (2087398) 2087398..2089260 + 1863 WP_040234481.1 glutathione-regulated potassium-efflux system protein KefC -
QRM68_RS11620 (2089452) 2089452..2089931 + 480 WP_001487721.1 type 3 dihydrofolate reductase -
QRM68_RS11625 (2090017) 2090017..2090250 + 234 WP_000125565.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
QRM68_RS11630 (2090253) 2090253..2090567 + 315 WP_001160975.1 CcdB family protein Toxin
QRM68_RS11635 (2090564) 2090564..2091412 - 849 WP_021556397.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
QRM68_RS11640 (2091419) 2091419..2091796 - 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
QRM68_RS11645 (2091799) 2091799..2092620 - 822 WP_001065381.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
QRM68_RS11650 (2092617) 2092617..2093606 - 990 WP_021556398.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
QRM68_RS11655 (2093606) 2093606..2094892 - 1287 WP_000800457.1 peptidylprolyl isomerase SurA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11711.76 Da        Isoelectric Point: 9.8517

>T284096 WP_001160975.1 NZ_CP127303:2090253-2090567 [Escherichia coli]
MQFTVYRSRSRNAAFPFVIDVTSDIIGVINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8599.64 Da        Isoelectric Point: 6.9791

>AT284096 WP_000125565.1 NZ_CP127303:2090017-2090250 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRRF

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A090NGC7

References