Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 1878318..1878913 Replicon chromosome
Accession NZ_CP127303
Organism Escherichia coli strain APEC37

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag QRM68_RS10660 Protein ID WP_000239579.1
Coordinates 1878563..1878913 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag QRM68_RS10655 Protein ID WP_001223208.1
Coordinates 1878318..1878569 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM68_RS10645 (1873982) 1873982..1877761 + 3780 WP_021557470.1 autotransporter assembly complex protein TamB -
QRM68_RS10650 (1877764) 1877764..1878105 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
QRM68_RS10655 (1878318) 1878318..1878569 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
QRM68_RS10660 (1878563) 1878563..1878913 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
QRM68_RS10665 (1878993) 1878993..1879523 - 531 WP_000055072.1 inorganic diphosphatase -
QRM68_RS10670 (1879833) 1879833..1880789 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
QRM68_RS10675 (1880929) 1880929..1882431 + 1503 WP_021557471.1 sugar ABC transporter ATP-binding protein -
QRM68_RS10680 (1882445) 1882445..1883467 + 1023 WP_001313531.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T284095 WP_000239579.1 NZ_CP127303:1878563-1878913 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT284095 WP_001223208.1 NZ_CP127303:1878318-1878569 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References