Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 1781284..1781781 Replicon chromosome
Accession NZ_CP127303
Organism Escherichia coli strain APEC37

Toxin (Protein)


Gene name ghoT Uniprot ID A0A163EQM5
Locus tag QRM68_RS10155 Protein ID WP_001672275.1
Coordinates 1781608..1781781 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag QRM68_RS10150 Protein ID WP_000398619.1
Coordinates 1781284..1781580 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM68_RS10130 (1778015) 1778015..1778734 - 720 WP_000611288.1 two-component system response regulator DcuR -
QRM68_RS10135 (1778731) 1778731..1780362 - 1632 WP_001216477.1 sensor histidine kinase -
QRM68_RS10140 (1780543) 1780543..1780773 + 231 WP_021557455.1 4Fe-4S mono-cluster protein YjdI -
QRM68_RS10145 (1780785) 1780785..1781057 + 273 WP_000405647.1 GNAT family N-acetyltransferase -
QRM68_RS10150 (1781284) 1781284..1781580 + 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QRM68_RS10155 (1781608) 1781608..1781781 + 174 WP_001672275.1 type V toxin-antitoxin system toxin GhoT Toxin
QRM68_RS10160 (1781900) 1781900..1783417 - 1518 WP_001295074.1 lysine--tRNA ligase -
QRM68_RS10165 (1783654) 1783654..1785111 - 1458 WP_021557456.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6569.09 Da        Isoelectric Point: 10.2288

>T284094 WP_001672275.1 NZ_CP127303:1781608-1781781 [Escherichia coli]
MALFSKILIFYVIGVNISFIIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT284094 WP_000398619.1 NZ_CP127303:1781284-1781580 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A163EQM5

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References