Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 929768..930399 Replicon chromosome
Accession NZ_CP127303
Organism Escherichia coli strain APEC37

Toxin (Protein)


Gene name hicA Uniprot ID A0A1M1UJK7
Locus tag QRM68_RS06115 Protein ID WP_001259382.1
Coordinates 930124..930399 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag QRM68_RS06110 Protein ID WP_000593555.1
Coordinates 929768..930127 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM68_RS06080 (924880) 924880..925353 + 474 WP_001161650.1 PTS sugar transporter subunit IIA -
QRM68_RS06085 (925350) 925350..925631 + 282 WP_000084025.1 PTS sugar transporter subunit IIB -
QRM68_RS06090 (925708) 925708..927066 + 1359 WP_001308116.1 PTS galactitol transporter subunit IIC -
QRM68_RS06095 (927059) 927059..928567 + 1509 WP_021557288.1 FGGY-family carbohydrate kinase -
QRM68_RS06100 (928557) 928557..928826 + 270 WP_000933060.1 HPr family phosphocarrier protein -
QRM68_RS06105 (928858) 928858..929718 + 861 WP_021557289.1 class II aldolase -
QRM68_RS06110 (929768) 929768..930127 - 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QRM68_RS06115 (930124) 930124..930399 - 276 WP_001259382.1 type II toxin-antitoxin system HicA family toxin Toxin
QRM68_RS06120 (930472) 930472..931596 - 1125 WP_021557290.1 ABC transporter permease -
QRM68_RS06125 (931596) 931596..934331 - 2736 WP_000149130.1 ribosome-associated ATPase/putative transporter RbbA -
QRM68_RS06130 (934328) 934328..935395 - 1068 WP_000361517.1 HlyD family efflux transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 924109..939255 15146


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10185.91 Da        Isoelectric Point: 10.7076

>T284092 WP_001259382.1 NZ_CP127303:c930399-930124 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKSPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT284092 WP_000593555.1 NZ_CP127303:c930127-929768 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M1UJK7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References