Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 323860..324514 Replicon chromosome
Accession NZ_CP127303
Organism Escherichia coli strain APEC37

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag QRM68_RS03030 Protein ID WP_000244777.1
Coordinates 323860..324267 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QRM68_RS03035 Protein ID WP_000354046.1
Coordinates 324248..324514 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM68_RS03010 (319817) 319817..321550 - 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -
QRM68_RS03015 (321556) 321556..322266 - 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QRM68_RS03020 (322291) 322291..323187 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QRM68_RS03025 (323299) 323299..323820 + 522 WP_001055874.1 flavodoxin FldB -
QRM68_RS03030 (323860) 323860..324267 - 408 WP_000244777.1 protein YgfX Toxin
QRM68_RS03035 (324248) 324248..324514 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QRM68_RS03040 (324757) 324757..325737 + 981 WP_001625883.1 tRNA-modifying protein YgfZ -
QRM68_RS03045 (325814) 325814..326473 - 660 WP_000250274.1 hemolysin III family protein -
QRM68_RS03050 (326637) 326637..326948 - 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
QRM68_RS03055 (326993) 326993..328426 + 1434 WP_021557183.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T284090 WP_000244777.1 NZ_CP127303:c324267-323860 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT284090 WP_000354046.1 NZ_CP127303:c324514-324248 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References