Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 174288..174871 Replicon chromosome
Accession NZ_CP127303
Organism Escherichia coli strain APEC37

Toxin (Protein)


Gene name mazF Uniprot ID U9XFN8
Locus tag QRM68_RS02365 Protein ID WP_000254745.1
Coordinates 174288..174623 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1M2U551
Locus tag QRM68_RS02370 Protein ID WP_021557150.1
Coordinates 174623..174871 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM68_RS02350 (170175) 170175..171473 - 1299 WP_000036723.1 phosphopyruvate hydratase -
QRM68_RS02355 (171561) 171561..173198 - 1638 WP_000210878.1 CTP synthase (glutamine hydrolyzing) -
QRM68_RS02360 (173426) 173426..174217 - 792 WP_001071643.1 nucleoside triphosphate pyrophosphohydrolase -
QRM68_RS02365 (174288) 174288..174623 - 336 WP_000254745.1 endoribonuclease MazF Toxin
QRM68_RS02370 (174623) 174623..174871 - 249 WP_021557150.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
QRM68_RS02375 (174949) 174949..177183 - 2235 WP_000226815.1 GTP pyrophosphokinase -
QRM68_RS02380 (177231) 177231..178532 - 1302 WP_021557151.1 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-109)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12158.08 Da        Isoelectric Point: 8.4777

>T284089 WP_000254745.1 NZ_CP127303:c174623-174288 [Escherichia coli]
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPYTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG

Download         Length: 336 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9383.79 Da        Isoelectric Point: 4.4665

>AT284089 WP_021557150.1 NZ_CP127303:c174871-174623 [Escherichia coli]
MIHSSVKRWGNSPAVRIPVTLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYM3

Antitoxin

Source ID Structure
AlphaFold DB A0A1M2U551

References