Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 153078..153703 Replicon plasmid pAPEC3701
Accession NZ_CP127301
Organism Escherichia coli strain APEC37

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QRM68_RS00845 Protein ID WP_000911313.1
Coordinates 153078..153476 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V0VCB2
Locus tag QRM68_RS00850 Protein ID WP_000450520.1
Coordinates 153476..153703 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM68_RS00830 (149349) 149349..149846 + 498 WP_000605857.1 entry exclusion protein -
QRM68_RS00835 (149878) 149878..150609 + 732 WP_130570567.1 conjugal transfer complement resistance protein TraT -
QRM68_RS00840 (150862) 150862..153069 + 2208 WP_174407540.1 type IV conjugative transfer system coupling protein TraD -
QRM68_RS00845 (153078) 153078..153476 - 399 WP_000911313.1 type II toxin-antitoxin system VapC family toxin Toxin
QRM68_RS00850 (153476) 153476..153703 - 228 WP_000450520.1 toxin-antitoxin system antitoxin VapB Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD vat / vat / iroN / iroN / iroE / iroD / iroC / iroB / iucA / iucB / iucB / iucC / iucC / iucD / iutA 1..192709 192709


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14901.15 Da        Isoelectric Point: 7.8605

>T284082 WP_000911313.1 NZ_CP127301:c153476-153078 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHS
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVDGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8596.63 Da        Isoelectric Point: 4.7513

>AT284082 WP_000450520.1 NZ_CP127301:c153703-153476 [Escherichia coli]
METTVFFSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHNVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V0VCB2

References