Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 94548..95191 Replicon plasmid pAPEC3701
Accession NZ_CP127301
Organism Escherichia coli strain APEC37

Toxin (Protein)


Gene name vagD Uniprot ID V0UN72
Locus tag QRM68_RS00465 Protein ID WP_001034044.1
Coordinates 94548..94964 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag QRM68_RS00470 Protein ID WP_088569139.1
Coordinates 94961..95191 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM68_RS00450 (90951) 90951..91648 + 698 WP_223155668.1 IS1-like element IS1A family transposase -
QRM68_RS00455 (91902) 91902..92924 - 1023 WP_000361402.1 helicase UvrD -
QRM68_RS00460 (92909) 92909..94473 - 1565 Protein_91 AAA family ATPase -
QRM68_RS00465 (94548) 94548..94964 - 417 WP_001034044.1 type II toxin-antitoxin system VapC family toxin Toxin
QRM68_RS00470 (94961) 94961..95191 - 231 WP_088569139.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QRM68_RS00475 (95248) 95248..96042 - 795 WP_000544809.1 IS21-like element helper ATPase IstB -
QRM68_RS00480 (96042) 96042..97214 - 1173 WP_000952425.1 IS21-like element ISEc62 family transposase -
QRM68_RS00485 (97707) 97707..99845 + 2139 WP_001513523.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD vat / vat / iroN / iroN / iroE / iroD / iroC / iroB / iucA / iucB / iucB / iucC / iucC / iucD / iutA 1..192709 192709


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15232.66 Da        Isoelectric Point: 6.8536

>T284076 WP_001034044.1 NZ_CP127301:c94964-94548 [Escherichia coli]
VNKIYMLDTNICSFIMREQPEALLKHLEQSVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCERLDAVLPWDRA
AVDATTEIKVALRLAGTPIGPNDTAIAGHAIAACAILVTNNVREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8761.89 Da        Isoelectric Point: 4.3895

>AT284076 WP_088569139.1 NZ_CP127301:c95191-94961 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLELEKAEPDFMTEREDVVSDEGRVNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CHW1

Antitoxin

Source ID Structure

References