Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 60881..61482 Replicon plasmid pAPEC201602
Accession NZ_CP127299
Organism Escherichia coli strain APEC20/16

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag QRM67_RS25410 Protein ID WP_286005028.1
Coordinates 61102..61482 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag QRM67_RS25405 Protein ID WP_001190712.1
Coordinates 60881..61102 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM67_RS25395 (QRM67_25400) 59378..59908 + 531 WP_032164697.1 membrane protein -
QRM67_RS25400 (QRM67_25405) 60162..60548 + 387 WP_286005027.1 helix-turn-helix transcriptional regulator -
QRM67_RS25405 (QRM67_25410) 60881..61102 + 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QRM67_RS25410 (QRM67_25415) 61102..61482 + 381 WP_286005028.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
QRM67_RS25415 (QRM67_25420) 61487..61666 + 180 WP_000113018.1 hypothetical protein -
QRM67_RS25420 (QRM67_25425) 61694..62737 + 1044 WP_104731269.1 DUF968 domain-containing protein -
QRM67_RS25425 (QRM67_25430) 62826..63278 + 453 WP_001326849.1 late promoter-activating protein -
QRM67_RS25430 (QRM67_25435) 63364..64557 + 1194 WP_104731270.1 terminase -
QRM67_RS25435 (QRM67_25440) 64599..66041 + 1443 WP_226474765.1 terminase -
QRM67_RS25440 (QRM67_25445) 66255..66356 + 102 Protein_68 transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..102041 102041


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(4-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13614.34 Da        Isoelectric Point: 5.6343

>T284072 WP_286005028.1 NZ_CP127299:61102-61482 [Escherichia coli]
MRHISPEELIALHDANINRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELANLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT284072 WP_001190712.1 NZ_CP127299:60881-61102 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References