Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 190651..191449 Replicon chromosome
Accession NC_018704
Organism Amphibacillus xylanus NBRC 15112

Toxin (Protein)


Gene name - Uniprot ID K0IV68
Locus tag AXY_RS01015 Protein ID WP_015008920.1
Coordinates 190651..191124 (-) Length 158 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag AXY_RS01020 Protein ID WP_015008921.1
Coordinates 191129..191449 (-) Length 107 a.a.

Genomic Context


AXY_RS01030AXY_RS01035AXY_RS01040AXY_RS01045AXY_RS01050AXY_RS12700AXY_RS01055AXY_RS12160AXY_RS01010AXY_RS01015AXY_RS01020AXY_RS01025
Location: 192374..192556 (183 bp)
Type: Others
Protein ID: WP_015008923.1
Location: 192570..192764 (195 bp)
Type: Others
Protein ID: WP_015008924.1
Location: 192826..193152 (327 bp)
Type: Others
Protein ID: WP_015008925.1
Location: 193244..194041 (798 bp)
Type: Others
Protein ID: WP_015008926.1
Location: 194042..194302 (261 bp)
Type: Others
Protein ID: WP_015008927.1
Location: 194310..194471 (162 bp)
Type: Others
Protein ID: WP_015008928.1
Location: 194458..195210 (753 bp)
Type: Others
Protein ID: WP_015008929.1
Location: 195284..196333 (1050 bp)
Type: Others
Protein ID: WP_015008930.1
Location: 189410..190570 (1161 bp)
Type: Others
Protein ID: WP_015008919.1
Location: 190651..191124 (474 bp)
Type: Toxin
Protein ID: WP_015008920.1
Location: 191129..191449 (321 bp)
Type: Antitoxin
Protein ID: WP_015008921.1
Location: 191981..192310 (330 bp)
Type: Others
Protein ID: WP_041450062.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AXY_RS01010189410..190570-1161WP_015008919.1site-specific integrase-
AXY_RS01015190651..191124-474WP_015008920.1ImmA/IrrE family metallo-endopeptidaseToxin
AXY_RS01020191129..191449-321WP_015008921.1helix-turn-helix domain-containing proteinAntitoxin
AXY_RS01025191981..192310-330WP_041450062.1hypothetical protein-
AXY_RS01030192374..192556+183WP_015008923.1helix-turn-helix domain-containing protein-
AXY_RS01035192570..192764+195WP_015008924.1hypothetical protein-
AXY_RS01040192826..193152+327WP_015008925.1hypothetical protein-
AXY_RS01045193244..194041+798WP_015008926.1hypothetical protein-
AXY_RS01050194042..194302+261WP_015008927.1hypothetical protein-
AXY_RS12700194310..194471+162WP_015008928.1hypothetical protein-
AXY_RS01055194458..195210+753WP_015008929.1phage antirepressor KilAC domain-containing protein-
AXY_RS12160195284..196333+1050WP_015008930.1DnaD domain protein-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--189410..23771548305


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(10-122)

Antitoxin

(6-64)


Sequences


Toxin        


Download         Length: 158 a.a.        Molecular weight: 18512.33 Da        Isoelectric Point: 7.7773

>T28407 WP_015008920.1 NC_018704:c191124-190651 [Amphibacillus xylanus NBRC 15112]
MQYEKLLIEADQHGVDIYEKPMQKRNKGLYCDKVIWINKYINTSTEKACVLAEELGHYHTSAGNILDQKNLNNIKQEKQA
RTWAYEKLVPLKKIIKAHKDGPKNKYELAEYLGVTEDFLEKAIERYIEKFGLSVKYKDYVICFEPLGVIEWFDNKNF

Download         Length: 474 bp

>T28407 NC_018704:c191124-190651 [Amphibacillus xylanus NBRC 15112]
ATGCAATATGAAAAACTTCTTATAGAGGCAGATCAACATGGAGTAGACATCTATGAAAAGCCAATGCAGAAGAGAAATAA
AGGTTTATACTGTGACAAAGTTATTTGGATAAATAAATACATAAATACATCCACAGAAAAAGCCTGTGTTCTAGCTGAAG
AACTTGGCCATTATCATACATCAGCAGGTAACATACTTGATCAAAAAAATTTAAACAACATAAAACAAGAAAAGCAAGCT
CGTACATGGGCATATGAAAAATTAGTTCCATTAAAGAAAATTATTAAAGCACATAAAGATGGTCCAAAAAATAAGTATGA
GCTTGCAGAATATTTAGGAGTAACTGAAGATTTTCTAGAAAAAGCGATTGAACGTTATATTGAGAAGTTTGGTTTATCTG
TTAAGTATAAAGACTATGTAATCTGCTTTGAACCACTTGGTGTAATTGAGTGGTTTGATAATAAAAATTTTTAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12616.10 Da        Isoelectric Point: 4.7484

>AT28407 WP_015008921.1 NC_018704:c191449-191129 [Amphibacillus xylanus NBRC 15112]
MTAFDRVKKLCEEQKISIVELEEKVGFGRNSLYSWKKNNPSSEKLEKVADFFNVSTDYLLGRTDIKYIHEPDTIAAHHDG
EDWTEEELEEIERFKEFVRMKRSQQE

Download         Length: 321 bp

>AT28407 NC_018704:c191449-191129 [Amphibacillus xylanus NBRC 15112]
ATGACTGCTTTTGATAGAGTAAAAAAATTATGTGAGGAACAAAAAATTTCTATTGTGGAACTAGAGGAAAAGGTTGGATT
TGGTAGAAACTCTTTATACTCTTGGAAGAAAAACAATCCTTCTTCTGAGAAATTAGAAAAAGTAGCAGACTTTTTCAACG
TCTCCACCGATTATCTATTAGGTCGTACAGATATAAAATACATACATGAGCCAGACACAATCGCAGCTCATCACGATGGA
GAGGACTGGACAGAAGAAGAATTAGAAGAAATAGAACGATTTAAAGAATTTGTAAGAATGAAGAGAAGCCAGCAGGAGTG
A

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBK0IV68


Antitoxin

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Source
ID
Structure
No matching records found

References