Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4807404..4807901 Replicon chromosome
Accession NZ_CP127297
Organism Escherichia coli strain APEC20/16

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QRM67_RS23680 Protein ID WP_001173343.1
Coordinates 4807404..4807577 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag QRM67_RS23685 Protein ID WP_000398619.1
Coordinates 4807605..4807901 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM67_RS23670 (4804074) 4804074..4805531 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
QRM67_RS23675 (4805768) 4805768..4807285 + 1518 WP_001295074.1 lysine--tRNA ligase -
QRM67_RS23680 (4807404) 4807404..4807577 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QRM67_RS23685 (4807605) 4807605..4807901 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QRM67_RS23690 (4808128) 4808128..4808400 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
QRM67_RS23695 (4808412) 4808412..4808642 - 231 WP_000371700.1 4Fe-4S mono-cluster protein YjdI -
QRM67_RS23700 (4808823) 4808823..4810454 + 1632 WP_001216486.1 sensor histidine kinase -
QRM67_RS23705 (4810451) 4810451..4811170 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T284069 WP_001173343.1 NZ_CP127297:c4807577-4807404 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT284069 WP_000398619.1 NZ_CP127297:c4807901-4807605 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References