Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3991444..3992062 Replicon chromosome
Accession NZ_CP127297
Organism Escherichia coli strain APEC20/16

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QRM67_RS19670 Protein ID WP_001291435.1
Coordinates 3991844..3992062 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QRM67_RS19665 Protein ID WP_000344800.1
Coordinates 3991444..3991818 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM67_RS19655 (3986533) 3986533..3987726 + 1194 WP_286004877.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QRM67_RS19660 (3987749) 3987749..3990898 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QRM67_RS19665 (3991444) 3991444..3991818 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QRM67_RS19670 (3991844) 3991844..3992062 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QRM67_RS19675 (3992234) 3992234..3992785 + 552 WP_000102564.1 maltose O-acetyltransferase -
QRM67_RS19680 (3992901) 3992901..3993371 + 471 WP_000136192.1 YlaC family protein -
QRM67_RS19685 (3993535) 3993535..3995085 + 1551 WP_001364591.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QRM67_RS19690 (3995127) 3995127..3995480 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QRM67_RS19700 (3995859) 3995859..3996170 + 312 WP_000409911.1 MGMT family protein -
QRM67_RS19705 (3996201) 3996201..3996773 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T284066 WP_001291435.1 NZ_CP127297:3991844-3992062 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT284066 WP_000344800.1 NZ_CP127297:3991444-3991818 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References