Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2939483..2940121 Replicon chromosome
Accession NZ_CP127297
Organism Escherichia coli strain APEC20/16

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag QRM67_RS14435 Protein ID WP_000813794.1
Coordinates 2939945..2940121 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QRM67_RS14430 Protein ID WP_001270286.1
Coordinates 2939483..2939899 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM67_RS14410 (2934635) 2934635..2935576 - 942 WP_001251315.1 ABC transporter permease -
QRM67_RS14415 (2935577) 2935577..2936590 - 1014 WP_078206008.1 ABC transporter ATP-binding protein -
QRM67_RS14420 (2936608) 2936608..2937753 - 1146 WP_000047456.1 ABC transporter substrate-binding protein -
QRM67_RS14425 (2937998) 2937998..2939404 - 1407 WP_000760629.1 PLP-dependent aminotransferase family protein -
QRM67_RS14430 (2939483) 2939483..2939899 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QRM67_RS14435 (2939945) 2939945..2940121 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QRM67_RS14440 (2940343) 2940343..2940573 + 231 WP_000494244.1 YncJ family protein -
QRM67_RS14445 (2940665) 2940665..2942626 - 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QRM67_RS14450 (2942699) 2942699..2943235 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
QRM67_RS14455 (2943288) 2943288..2944502 + 1215 WP_071601296.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2944542..2945690 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T284065 WP_000813794.1 NZ_CP127297:c2940121-2939945 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT284065 WP_001270286.1 NZ_CP127297:c2939899-2939483 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References