Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2761346..2761872 Replicon chromosome
Accession NZ_CP127297
Organism Escherichia coli strain APEC20/16

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag QRM67_RS13590 Protein ID WP_078205922.1
Coordinates 2761585..2761872 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag QRM67_RS13585 Protein ID WP_000534858.1
Coordinates 2761346..2761585 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM67_RS13550 (2756680) 2756680..2757169 + 490 Protein_2632 class I SAM-dependent methyltransferase -
QRM67_RS13555 (2757647) 2757647..2758068 + 422 Protein_2633 hypothetical protein -
QRM67_RS13560 (2758703) 2758703..2759074 + 372 WP_001406656.1 helix-turn-helix domain-containing protein -
QRM67_RS13565 (2759112) 2759112..2759774 + 663 Protein_2635 IS1202-like element ISEsa1 family transposase -
QRM67_RS13570 (2759895) 2759895..2760044 + 150 WP_011443592.1 protein YdfW -
QRM67_RS13575 (2760481) 2760481..2760813 - 333 WP_001317460.1 FlxA-like family protein -
QRM67_RS13580 (2761016) 2761016..2761321 - 306 WP_001326990.1 protein YdfV -
QRM67_RS13585 (2761346) 2761346..2761585 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
QRM67_RS13590 (2761585) 2761585..2761872 + 288 WP_078205922.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
QRM67_RS13595 (2761944) 2761944..2762099 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
QRM67_RS13600 (2762316) 2762316..2762567 + 252 WP_000980994.1 protein Rem -
QRM67_RS13605 (2762634) 2762634..2762912 + 279 WP_222699532.1 hypothetical protein -
QRM67_RS13610 (2762914) 2762914..2763963 + 1050 WP_001265198.1 DUF968 domain-containing protein -
QRM67_RS13615 (2763977) 2763977..2764729 + 753 WP_286004827.1 antitermination protein -
QRM67_RS13620 (2765007) 2765007..2765096 - 90 WP_120795389.1 hypothetical protein -
QRM67_RS13625 (2765151) 2765151..2765363 - 213 WP_000087756.1 cold shock-like protein CspF -
QRM67_RS13630 (2765664) 2765664..2765879 + 216 WP_000066484.1 cold shock-like protein CspB -
QRM67_RS13635 (2766243) 2766243..2766413 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
QRM67_RS13640 (2766633) 2766633..2766848 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2748071..2799868 51797


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11255.24 Da        Isoelectric Point: 10.1967

>T284063 WP_078205922.1 NZ_CP127297:2761585-2761872 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSSYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT284063 WP_000534858.1 NZ_CP127297:2761346-2761585 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References