Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1711450..1712075 Replicon chromosome
Accession NZ_CP127297
Organism Escherichia coli strain APEC20/16

Toxin (Protein)


Gene name vapC Uniprot ID A0A8S7SZU1
Locus tag QRM67_RS08260 Protein ID WP_000911327.1
Coordinates 1711677..1712075 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag QRM67_RS08255 Protein ID WP_000450524.1
Coordinates 1711450..1711677 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM67_RS08230 (1707252) 1707252..1707722 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
QRM67_RS08235 (1707722) 1707722..1708294 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
QRM67_RS08240 (1708440) 1708440..1709318 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
QRM67_RS08245 (1709335) 1709335..1710369 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
QRM67_RS08250 (1710582) 1710582..1711295 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
QRM67_RS08255 (1711450) 1711450..1711677 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
QRM67_RS08260 (1711677) 1711677..1712075 + 399 WP_000911327.1 type II toxin-antitoxin system VapC family toxin Toxin
QRM67_RS08265 (1712222) 1712222..1713085 + 864 WP_001267508.1 neutral zinc metallopeptidase -
QRM67_RS08270 (1713100) 1713100..1715115 + 2016 WP_000829329.1 tRNA cytosine(34) acetyltransferase TmcA -
QRM67_RS08275 (1715189) 1715189..1715887 + 699 WP_000679823.1 esterase -
QRM67_RS08280 (1715997) 1715997..1716197 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T284057 WP_000911327.1 NZ_CP127297:1711677-1712075 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMEIIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT284057 WP_000450524.1 NZ_CP127297:1711450-1711677 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References