Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1269030..1269684 Replicon chromosome
Accession NZ_CP127297
Organism Escherichia coli strain APEC20/16

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag QRM67_RS06150 Protein ID WP_000244772.1
Coordinates 1269277..1269684 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QRM67_RS06145 Protein ID WP_000354046.1
Coordinates 1269030..1269296 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM67_RS06120 (1264318) 1264318..1265061 + 744 WP_000951964.1 SDR family oxidoreductase -
QRM67_RS06125 (1265118) 1265118..1266551 - 1434 WP_001344773.1 6-phospho-beta-glucosidase BglA -
QRM67_RS06130 (1266596) 1266596..1266907 + 312 WP_286004956.1 N(4)-acetylcytidine aminohydrolase -
QRM67_RS06135 (1267071) 1267071..1267730 + 660 WP_000250274.1 hemolysin III family protein -
QRM67_RS06140 (1267807) 1267807..1268787 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
QRM67_RS06145 (1269030) 1269030..1269296 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QRM67_RS06150 (1269277) 1269277..1269684 + 408 WP_000244772.1 protein YgfX Toxin
QRM67_RS06155 (1269724) 1269724..1270245 - 522 WP_001055874.1 flavodoxin FldB -
QRM67_RS06160 (1270357) 1270357..1271253 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QRM67_RS06165 (1271278) 1271278..1271988 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QRM67_RS06170 (1271994) 1271994..1273727 + 1734 WP_000813215.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T284055 WP_000244772.1 NZ_CP127297:1269277-1269684 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT284055 WP_000354046.1 NZ_CP127297:1269030-1269296 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References