Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 609780..610411 Replicon chromosome
Accession NZ_CP127297
Organism Escherichia coli strain APEC20/16

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag QRM67_RS02800 Protein ID WP_001259385.1
Coordinates 609780..610055 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q31VE4
Locus tag QRM67_RS02805 Protein ID WP_000593554.1
Coordinates 610052..610411 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM67_RS02780 (604785) 604785..604898 + 114 WP_001296785.1 protein YhiY -
QRM67_RS02785 (604961) 604961..606028 + 1068 WP_000361485.1 HlyD family secretion protein -
QRM67_RS02790 (606025) 606025..608760 + 2736 WP_028132003.1 ribosome-associated ATPase/putative transporter RbbA -
QRM67_RS02795 (608760) 608760..609707 + 948 WP_222699587.1 ABC transporter permease -
QRM67_RS02800 (609780) 609780..610055 + 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
QRM67_RS02805 (610052) 610052..610411 + 360 WP_000593554.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QRM67_RS02810 (610461) 610461..611321 - 861 WP_001131783.1 class II aldolase -
QRM67_RS02815 (611353) 611353..611622 - 270 WP_000933060.1 HPr family phosphocarrier protein -
QRM67_RS02820 (611612) 611612..613120 - 1509 WP_001298718.1 FGGY-family carbohydrate kinase -
QRM67_RS02825 (613113) 613113..614471 - 1359 WP_001298729.1 PTS galactitol transporter subunit IIC -
QRM67_RS02830 (614548) 614548..614829 - 282 WP_000084022.1 PTS sugar transporter subunit IIB -
QRM67_RS02835 (614826) 614826..615299 - 474 WP_001161553.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T284052 WP_001259385.1 NZ_CP127297:609780-610055 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13359.25 Da        Isoelectric Point: 4.8838

>AT284052 WP_000593554.1 NZ_CP127297:610052-610411 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLLEYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A6H2GM94

References