Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 3808144..3808829 Replicon chromosome
Accession NZ_CP127277
Organism Mycobacterium tuberculosis strain 25421

Toxin (Protein)


Gene name vapC Uniprot ID G0TIR9
Locus tag QRF07_RS17935 Protein ID WP_003417998.1
Coordinates 3808419..3808829 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag QRF07_RS17930 Protein ID WP_180895138.1
Coordinates 3808144..3808422 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF07_RS17910 (QRF07_17910) 3804133..3805734 - 1602 WP_003417969.1 FAD/NAD(P)-binding protein -
QRF07_RS17915 (QRF07_17915) 3805751..3806455 - 705 WP_003417980.1 dTDP-4-amino-4,6-dideoxyglucose formyltransferase -
QRF07_RS17920 (QRF07_17920) 3806573..3807139 - 567 WP_003417984.1 TetR/AcrR family transcriptional regulator -
QRF07_RS17925 (QRF07_17925) 3807201..3808088 + 888 WP_003900050.1 alpha-ketoglutarate-dependent sulfate ester dioxygenase -
QRF07_RS17930 (QRF07_17930) 3808144..3808422 + 279 WP_180895138.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QRF07_RS17935 (QRF07_17935) 3808419..3808829 + 411 WP_003417998.1 type II toxin-antitoxin system VapC family toxin Toxin
QRF07_RS17940 (QRF07_17940) 3808862..3810598 - 1737 WP_003418002.1 cholesterol oxidase -
QRF07_RS17945 (QRF07_17945) 3810654..3811781 - 1128 WP_003418005.1 GuaB3 family IMP dehydrogenase-related protein -
QRF07_RS17950 (QRF07_17950) 3811801..3813390 - 1590 WP_003901630.1 IMP dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-118)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-58)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14695.84 Da        Isoelectric Point: 5.1784

>T284049 WP_003417998.1 NZ_CP127277:3808419-3808829 [Mycobacterium tuberculosis]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVELMRVVARYGQPGQTERARYLLDGLDILPLTEPVIG
LAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Download         Length: 411 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10227.70 Da        Isoelectric Point: 8.0222

>AT284049 WP_180895138.1 NZ_CP127277:3808144-3808422 [Mycobacterium tuberculosis]
VEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEPARGCKRT
LSDVLNEMRDEQ

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIR9

Antitoxin

Source ID Structure

References