Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3752644..3753173 Replicon chromosome
Accession NZ_CP127277
Organism Mycobacterium tuberculosis strain 25421

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag QRF07_RS17675 Protein ID WP_003417760.1
Coordinates 3752916..3753173 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag QRF07_RS17670 Protein ID WP_003417757.1
Coordinates 3752644..3752919 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF07_RS17635 (QRF07_17635) 3749217..3749906 - 690 WP_003917774.1 BBE domain-containing protein -
QRF07_RS17640 (QRF07_17640) 3750093..3750464 - 372 WP_003417739.1 FAD-binding protein -
QRF07_RS17645 (QRF07_17645) 3750362..3750580 - 219 WP_157132559.1 hypothetical protein -
QRF07_RS17650 (QRF07_17650) 3750607..3750867 - 261 WP_003417741.1 hypothetical protein -
QRF07_RS17655 (QRF07_17655) 3750982..3751371 + 390 WP_003417745.1 DUF732 domain-containing protein -
QRF07_RS17660 (QRF07_17660) 3751385..3751678 - 294 WP_003417749.1 DUF3017 domain-containing protein -
QRF07_RS17665 (QRF07_17665) 3751675..3752520 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
QRF07_RS17670 (QRF07_17670) 3752644..3752919 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
QRF07_RS17675 (QRF07_17675) 3752916..3753173 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
QRF07_RS17680 (QRF07_17680) 3753215..3754405 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
QRF07_RS17685 (QRF07_17685) 3754522..3754890 + 369 WP_003417765.1 FHA domain-containing protein -
QRF07_RS17690 (QRF07_17690) 3754887..3755438 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
QRF07_RS17695 (QRF07_17695) 3755445..3756026 - 582 WP_003417769.1 ATP/GTP-binding protein -
QRF07_RS17700 (QRF07_17700) 3756007..3756375 - 369 WP_003417772.1 DUF742 domain-containing protein -
QRF07_RS17705 (QRF07_17705) 3756353..3756745 - 393 WP_003417776.1 serine protease inhibitor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T284047 WP_003417760.1 NZ_CP127277:3752916-3753173 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT284047 WP_003417757.1 NZ_CP127277:3752644-3752919 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References