Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3092225..3092795 Replicon chromosome
Accession NZ_CP127277
Organism Mycobacterium tuberculosis strain 25421

Toxin (Protein)


Gene name mazF Uniprot ID P71650
Locus tag QRF07_RS14730 Protein ID WP_003414166.1
Coordinates 3092225..3092581 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL61
Locus tag QRF07_RS14735 Protein ID WP_003901465.1
Coordinates 3092565..3092795 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF07_RS14710 (QRF07_14710) 3087677..3089365 - 1689 WP_003414155.1 alpha/beta hydrolase family protein -
QRF07_RS14715 (QRF07_14715) 3089369..3089695 - 327 WP_003414157.1 hypothetical protein -
QRF07_RS14720 (QRF07_14720) 3089868..3090455 + 588 WP_003914429.1 DUF3558 family protein -
QRF07_RS14725 (QRF07_14725) 3090474..3092123 + 1650 WP_031653623.1 CocE/NonD family hydrolase -
QRF07_RS14730 (QRF07_14730) 3092225..3092581 - 357 WP_003414166.1 type II toxin-antitoxin system toxin endoribonuclease MazF9 Toxin
QRF07_RS14735 (QRF07_14735) 3092565..3092795 - 231 WP_003901465.1 type II toxin-antitoxin system antitoxin MazE9 Antitoxin
QRF07_RS14740 (QRF07_14740) 3092838..3093881 - 1044 WP_003414172.1 DUF2293 domain-containing protein -
QRF07_RS14745 (QRF07_14745) 3093880..3094347 + 468 WP_003414177.1 DUF1778 domain-containing protein -
QRF07_RS14750 (QRF07_14750) 3094523..3094777 - 255 WP_003917684.1 hypothetical protein -
QRF07_RS14755 (QRF07_14755) 3094925..3095329 + 405 WP_003414181.1 hypothetical protein -
QRF07_RS14760 (QRF07_14760) 3095326..3095517 + 192 WP_003414184.1 hypothetical protein -
QRF07_RS14765 (QRF07_14765) 3095734..3095994 + 261 Protein_2914 transposase -
QRF07_RS14770 (QRF07_14770) 3097104..3097361 + 258 WP_003899489.1 hypothetical protein -
QRF07_RS14775 (QRF07_14775) 3097466..3097777 + 312 WP_003414190.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-29)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12858.73 Da        Isoelectric Point: 9.1962

>T284040 WP_003414166.1 NZ_CP127277:c3092581-3092225 [Mycobacterium tuberculosis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS

Download         Length: 357 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8231.01 Da        Isoelectric Point: 4.1809

>AT284040 WP_003901465.1 NZ_CP127277:c3092795-3092565 [Mycobacterium tuberculosis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L2A
PDB 5HJZ
PDB 6KYT
PDB 6L29
PDB 7DU5
PDB 6KYS

Antitoxin

Source ID Structure
PDB 7DU5
PDB 6KYT
AlphaFold DB A0A7U4FBW3

References