Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2790141..2790793 Replicon chromosome
Accession NZ_CP127277
Organism Mycobacterium tuberculosis strain 25421

Toxin (Protein)


Gene name vapC Uniprot ID A0A5R1ZCY8
Locus tag QRF07_RS13115 Protein ID WP_003905869.1
Coordinates 2790368..2790793 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag QRF07_RS13110 Protein ID WP_003412749.1
Coordinates 2790141..2790362 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF07_RS13095 (QRF07_13095) 2788381..2788587 - 207 WP_003899347.1 hypothetical protein -
QRF07_RS13100 (QRF07_13100) 2788723..2789346 + 624 WP_003900858.1 TIGR00725 family protein -
QRF07_RS13105 (QRF07_13105) 2789336..2790088 + 753 WP_003901416.1 hypothetical protein -
QRF07_RS13110 (QRF07_13110) 2790141..2790362 + 222 WP_003412749.1 antitoxin Antitoxin
QRF07_RS13115 (QRF07_13115) 2790368..2790793 + 426 WP_003905869.1 type II toxin-antitoxin system VapC family toxin Toxin
QRF07_RS13120 (QRF07_13120) 2790816..2791997 - 1182 WP_003905870.1 dihydrolipoamide acetyltransferase family protein -
QRF07_RS13125 (QRF07_13125) 2791994..2793040 - 1047 WP_003412757.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
QRF07_RS13130 (QRF07_13130) 2793051..2794154 - 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
QRF07_RS13135 (QRF07_13135) 2794413..2795234 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
QRF07_RS13140 (QRF07_13140) 2795231..2795788 - 558 WP_003412768.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15364.84 Da        Isoelectric Point: 9.2386

>T284031 WP_003905869.1 NZ_CP127277:2790368-2790793 [Mycobacterium tuberculosis]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRASTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT284031 WP_003412749.1 NZ_CP127277:2790141-2790362 [Mycobacterium tuberculosis]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5R1ZCY8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References