Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parDE/- |
Location | 2384814..2385343 | Replicon | chromosome |
Accession | NZ_CP127277 | ||
Organism | Mycobacterium tuberculosis strain 25421 |
Toxin (Protein)
Gene name | parE | Uniprot ID | G0TMR4 |
Locus tag | QRF07_RS11195 | Protein ID | WP_003411124.1 |
Coordinates | 2384814..2385131 (-) | Length | 106 a.a. |
Antitoxin (Protein)
Gene name | parD | Uniprot ID | P9WJ74 |
Locus tag | QRF07_RS11200 | Protein ID | WP_003411127.1 |
Coordinates | 2385128..2385343 (-) | Length | 72 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
QRF07_RS11165 (QRF07_11165) | 2379951..2381027 | + | 1077 | WP_003411110.1 | hypothetical protein | - |
QRF07_RS11170 (QRF07_11170) | 2381024..2381305 | + | 282 | WP_003411112.1 | DUF5703 family protein | - |
QRF07_RS11175 (QRF07_11175) | 2381341..2382414 | + | 1074 | WP_003901338.1 | quinone-dependent dihydroorotate dehydrogenase | - |
QRF07_RS11180 (QRF07_11180) | 2382419..2382949 | - | 531 | WP_003411119.1 | YbhB/YbcL family Raf kinase inhibitor-like protein | - |
QRF07_RS11185 (QRF07_11185) | 2382997..2384343 | - | 1347 | WP_003411121.1 | M20/M25/M40 family metallo-hydrolase | - |
QRF07_RS11195 (QRF07_11195) | 2384814..2385131 | - | 318 | WP_003411124.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
QRF07_RS11200 (QRF07_11200) | 2385128..2385343 | - | 216 | WP_003411127.1 | antitoxin ParD2 | Antitoxin |
QRF07_RS11205 (QRF07_11205) | 2385598..2386656 | + | 1059 | WP_003411129.1 | phosphoribosyltransferase family protein | - |
QRF07_RS11210 (QRF07_11210) | 2386786..2387142 | - | 357 | WP_003411130.1 | hypothetical protein | - |
QRF07_RS11215 (QRF07_11215) | 2387237..2388019 | - | 783 | WP_003411131.1 | cell wall synthesis protein Wag31 | - |
QRF07_RS11220 (QRF07_11220) | 2388287..2388577 | - | 291 | WP_003900476.1 | YggT family protein | - |
QRF07_RS11225 (QRF07_11225) | 2388739..2389395 | - | 657 | WP_003411133.1 | cell division protein SepF | - |
QRF07_RS11230 (QRF07_11230) | 2389461..2390237 | - | 777 | WP_003411137.1 | YggS family pyridoxal phosphate-dependent enzyme | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12312.88 Da Isoelectric Point: 6.4831
>T284030 WP_003411124.1 NZ_CP127277:c2385131-2384814 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE
Download Length: 318 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TMR4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4FAJ4 |