Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3247759..3248420 Replicon chromosome
Accession NC_018700
Organism Sinorhizobium meliloti Rm41

Toxin (Protein)


Gene name vapC Uniprot ID H0G400
Locus tag BN406_RS15695 Protein ID WP_003531794.1
Coordinates 3247759..3248163 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID H0G3Z9
Locus tag BN406_RS15700 Protein ID WP_003531793.1
Coordinates 3248160..3248420 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN406_RS15680 3243355..3244467 + 1113 WP_003535893.1 3-isopropylmalate dehydrogenase -
BN406_RS15685 3244596..3245303 + 708 WP_003535894.1 phosphatase PAP2 family protein -
BN406_RS15690 3245404..3247293 - 1890 WP_003535895.1 MHS family MFS transporter -
BN406_RS15695 3247759..3248163 - 405 WP_003531794.1 type II toxin-antitoxin system VapC family toxin Toxin
BN406_RS15700 3248160..3248420 - 261 WP_003531793.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BN406_RS15710 3248833..3249867 + 1035 WP_003531790.1 aspartate-semialdehyde dehydrogenase -
BN406_RS15715 3250040..3250861 + 822 WP_003531785.1 lytic transglycosylase family protein -
BN406_RS15720 3251208..3251891 - 684 WP_010970569.1 carbonic anhydrase -
BN406_RS15725 3252065..3252946 - 882 WP_015008003.1 pyridoxal kinase PdxY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(8-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14480.69 Da        Isoelectric Point: 6.7257

>T28403 WP_003531794.1 NC_018700:c3248163-3247759 [Sinorhizobium meliloti Rm41]
VISHILDTSAVIALIGRKSDALVTRVLHSPQGIIGLPSVVAYELYFGAQKSAKAQHNLETLRLLMADFPILDFDRNDAFV
AGEIRAALAAKGTPIGPYDVLIAGQAKARGLTLVTNNVGEFNRVENLRVEDWSL

Download         Length: 405 bp

>T28403 NC_018700:c3248163-3247759 [Sinorhizobium meliloti Rm41]
GTGATCTCCCATATTCTCGACACCAGCGCCGTCATCGCTTTGATCGGGCGCAAATCGGATGCATTGGTCACCCGTGTACT
CCATAGCCCTCAGGGCATTATCGGGCTCCCGTCGGTCGTCGCGTATGAACTCTATTTTGGAGCGCAGAAAAGCGCGAAGG
CCCAACACAATCTCGAAACCCTGCGTTTGTTGATGGCGGATTTTCCGATCCTCGACTTCGACCGGAACGATGCCTTTGTC
GCAGGCGAGATCCGGGCCGCCCTTGCCGCGAAGGGTACGCCCATCGGACCTTATGACGTGCTGATTGCGGGACAGGCCAA
AGCCCGTGGATTGACGCTCGTCACCAACAATGTCGGCGAGTTCAATAGGGTTGAGAACCTGCGCGTGGAGGATTGGTCGC
TCTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9913.20 Da        Isoelectric Point: 5.1253

>AT28403 WP_003531793.1 NC_018700:c3248420-3248160 [Sinorhizobium meliloti Rm41]
MPHLARVFQSGNSQAVRLPKEFRFNVDRVEITQEGDALILRPHVEQGEQWSSLKAALARGMSEDFMMCGREQPEQQDRPE
LDAVFR

Download         Length: 261 bp

>AT28403 NC_018700:c3248420-3248160 [Sinorhizobium meliloti Rm41]
ATGCCCCATCTTGCACGGGTGTTCCAGTCCGGAAATTCGCAGGCCGTCCGCCTGCCTAAGGAATTCCGCTTCAACGTCGA
TCGCGTCGAAATCACGCAGGAAGGCGACGCGCTCATTCTCCGCCCGCACGTCGAGCAAGGCGAGCAGTGGTCATCGCTGA
AGGCGGCACTTGCCCGTGGCATGAGTGAAGACTTCATGATGTGCGGGCGCGAGCAGCCGGAACAGCAGGATCGGCCGGAA
CTCGACGCGGTATTTCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H0G400

Antitoxin

Source ID Structure
AlphaFold DB H0G3Z9

References