Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2346707..2347402 Replicon chromosome
Accession NZ_CP127277
Organism Mycobacterium tuberculosis strain 25421

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QRF07_RS10985 Protein ID WP_003905754.1
Coordinates 2346707..2347141 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag QRF07_RS10990 Protein ID WP_003410814.1
Coordinates 2347148..2347402 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF07_RS10975 (QRF07_10975) 2342861..2345902 + 3042 WP_003899171.1 DEAD/DEAH box helicase -
QRF07_RS10980 (QRF07_10980) 2345895..2346728 + 834 WP_003899172.1 SWIM zinc finger family protein -
QRF07_RS10985 (QRF07_10985) 2346707..2347141 - 435 WP_003905754.1 type II toxin-antitoxin system VapC family toxin Toxin
QRF07_RS10990 (QRF07_10990) 2347148..2347402 - 255 WP_003410814.1 antitoxin Antitoxin
QRF07_RS10995 (QRF07_10995) 2347418..2347675 - 258 WP_003410816.1 hypothetical protein -
QRF07_RS11000 (QRF07_11000) 2348086..2349347 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
QRF07_RS11005 (QRF07_11005) 2349980..2350276 + 297 WP_003410820.1 PE family protein -
QRF07_RS11010 (QRF07_11010) 2350332..2351063 + 732 WP_003900467.1 PPE family protein -
QRF07_RS11015 (QRF07_11015) 2351604..2352350 - 747 WP_003901330.1 proteasome subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15632.05 Da        Isoelectric Point: 7.4681

>T284029 WP_003905754.1 NZ_CP127277:c2347141-2346707 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTASEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT284029 WP_003410814.1 NZ_CP127277:c2347402-2347148 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References