Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2208034..2208722 Replicon chromosome
Accession NZ_CP127277
Organism Mycobacterium tuberculosis strain 25421

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag QRF07_RS10340 Protein ID WP_003409958.1
Coordinates 2208034..2208453 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag QRF07_RS10345 Protein ID WP_003409968.1
Coordinates 2208462..2208722 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF07_RS10320 (QRF07_10320) 2203529..2204377 + 849 WP_003901306.1 class I SAM-dependent methyltransferase -
QRF07_RS10325 (QRF07_10325) 2204340..2205785 - 1446 WP_003899115.1 APC family permease -
QRF07_RS10330 (QRF07_10330) 2205964..2206650 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
QRF07_RS10335 (QRF07_10335) 2206841..2207809 - 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
QRF07_RS10340 (QRF07_10340) 2208034..2208453 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
QRF07_RS10345 (QRF07_10345) 2208462..2208722 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QRF07_RS10350 (QRF07_10350) 2208865..2210541 + 1677 WP_003899118.1 PecA family PE domain-processing aspartic protease -
QRF07_RS10355 (QRF07_10355) 2210529..2211182 - 654 WP_003409976.1 cutinase Cfp21 -
QRF07_RS10360 (QRF07_10360) 2211297..2211527 + 231 WP_003409980.1 DUF167 domain-containing protein -
QRF07_RS10365 (QRF07_10365) 2211612..2212523 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
QRF07_RS10370 (QRF07_10370) 2212632..2213231 + 600 WP_003910883.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T284023 WP_003409958.1 NZ_CP127277:c2208453-2208034 [Mycobacterium tuberculosis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT284023 WP_003409968.1 NZ_CP127277:c2208722-2208462 [Mycobacterium tuberculosis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References