Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2177265..2177968 Replicon chromosome
Accession NZ_CP127277
Organism Mycobacterium tuberculosis strain 25421

Toxin (Protein)


Gene name mazF Uniprot ID G0TLK7
Locus tag QRF07_RS10130 Protein ID WP_003409778.1
Coordinates 2177265..2177594 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TLK8
Locus tag QRF07_RS10135 Protein ID WP_003409780.1
Coordinates 2177591..2177968 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF07_RS10110 (QRF07_10110) 2173648..2174718 + 1071 WP_003902252.1 epoxide hydrolase EphB -
QRF07_RS10115 (QRF07_10115) 2174715..2175230 + 516 WP_003409718.1 flavin reductase family protein -
QRF07_RS10120 (QRF07_10120) 2175227..2176288 + 1062 WP_003899092.1 3,4-dihydroxy-2-butanone-4-phosphate synthase -
QRF07_RS10125 (QRF07_10125) 2176285..2177055 + 771 WP_003409775.1 SDR family oxidoreductase -
QRF07_RS10130 (QRF07_10130) 2177265..2177594 - 330 WP_003409778.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QRF07_RS10135 (QRF07_10135) 2177591..2177968 - 378 WP_003409780.1 type II toxin-antitoxin system antitoxin MazE5 Antitoxin
QRF07_RS10140 (QRF07_10140) 2177965..2178555 - 591 WP_003409784.1 SEC-C metal-binding domain-containing protein -
QRF07_RS10145 (QRF07_10145) 2178610..2179974 + 1365 WP_003903691.1 HNH endonuclease signature motif containing protein -
QRF07_RS10150 (QRF07_10150) 2180129..2180581 - 453 WP_003899095.1 lipoprotein -
QRF07_RS10155 (QRF07_10155) 2180645..2181046 + 402 WP_003409869.1 hypothetical protein -
QRF07_RS10160 (QRF07_10160) 2181039..2181221 - 183 WP_003409870.1 hypothetical protein -
QRF07_RS10165 (QRF07_10165) 2181335..2181685 - 351 WP_003409871.1 hypothetical protein -
QRF07_RS10170 (QRF07_10170) 2181696..2182598 - 903 WP_003899097.1 hypothetical protein -
QRF07_RS10175 (QRF07_10175) 2182619..2182810 - 192 WP_003409876.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-103)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 11787.82 Da        Isoelectric Point: 8.5361

>T284020 WP_003409778.1 NZ_CP127277:c2177594-2177265 [Mycobacterium tuberculosis]
VTALPARGEVWWCEMAEIGRRPVVVLSRDAAIPRLRRALVAPCTTTIRGLASEVVLEPGSDPIPRRSAVNLDSVESVSVA
VLVNRLGRLADIRMRAICTALEVAVDCSR

Download         Length: 330 bp

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13560.07 Da        Isoelectric Point: 5.1519

>AT284020 WP_003409780.1 NZ_CP127277:c2177968-2177591 [Mycobacterium tuberculosis]
VKTARLQVTLRCAVDLINSSSDQCFARIEHVASDQADPRPGVWHSSGMNRIRLSTTVDAALLTSARDMRAGITDAALIDE
ALAALLARHRSAEVDASYAAYDKHPVDEPDEWGDLASWRRAAGDS

Download         Length: 378 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLK7

Antitoxin

Source ID Structure
AlphaFold DB G0TLK8

References