Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1958122..1958582 Replicon chromosome
Accession NZ_CP127277
Organism Mycobacterium tuberculosis strain 25421

Toxin (Protein)


Gene name vapC Uniprot ID G0TKL9
Locus tag QRF07_RS09155 Protein ID WP_003898996.1
Coordinates 1958334..1958582 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag QRF07_RS09150 Protein ID WP_003408528.1
Coordinates 1958122..1958334 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF07_RS09135 (QRF07_09135) 1954600..1955787 - 1188 WP_003898992.1 nitrate transporter NarK -
QRF07_RS09140 (QRF07_09140) 1956074..1956358 + 285 WP_003408522.1 DUF1876 domain-containing protein -
QRF07_RS09145 (QRF07_09145) 1956372..1958054 - 1683 WP_003901239.1 SulP family inorganic anion transporter -
QRF07_RS09150 (QRF07_09150) 1958122..1958334 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QRF07_RS09155 (QRF07_09155) 1958334..1958582 + 249 WP_003898996.1 type II toxin-antitoxin system VapC family toxin Toxin
QRF07_RS09160 (QRF07_09160) 1958590..1959327 + 738 WP_003898997.1 hypothetical protein -
QRF07_RS09165 (QRF07_09165) 1959421..1961121 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
QRF07_RS09170 (QRF07_09170) 1961406..1961807 - 402 WP_003408538.1 hypothetical protein -
QRF07_RS09175 (QRF07_09175) 1961797..1962408 - 612 WP_003898999.1 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8884.14 Da        Isoelectric Point: 4.1074

>T284019 WP_003898996.1 NZ_CP127277:1958334-1958582 [Mycobacterium tuberculosis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Download         Length: 249 bp

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT284019 WP_003408528.1 NZ_CP127277:1958122-1958334 [Mycobacterium tuberculosis]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TKL9

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References