Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1937447..1938060 Replicon chromosome
Accession NZ_CP127277
Organism Mycobacterium tuberculosis strain 25421

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag QRF07_RS09045 Protein ID WP_003408465.1
Coordinates 1937447..1937836 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag QRF07_RS09050 Protein ID WP_003408469.1
Coordinates 1937833..1938060 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF07_RS09010 (QRF07_09010) 1933076..1933990 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
QRF07_RS09015 (QRF07_09015) 1933993..1934823 + 831 WP_003408448.1 cyclase family protein -
QRF07_RS09020 (QRF07_09020) 1934823..1935173 + 351 WP_003898986.1 cupin domain-containing protein -
QRF07_RS09025 (QRF07_09025) 1935226..1936044 + 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
QRF07_RS09030 (QRF07_09030) 1936058..1936837 + 780 WP_003408460.1 IclR family transcriptional regulator -
QRF07_RS09040 (QRF07_09040) 1937268..1937399 + 132 Protein_1783 IS3 family transposase -
QRF07_RS09045 (QRF07_09045) 1937447..1937836 - 390 WP_003408465.1 type II toxin-antitoxin system VapC family toxin Toxin
QRF07_RS09050 (QRF07_09050) 1937833..1938060 - 228 WP_003408469.1 antitoxin Antitoxin
QRF07_RS09055 (QRF07_09055) 1938278..1939762 + 1485 WP_003408473.1 biotin carboxylase -
QRF07_RS09060 (QRF07_09060) 1939759..1941006 + 1248 WP_003408476.1 serine hydrolase -
QRF07_RS09065 (QRF07_09065) 1941049..1941468 - 420 WP_003408483.1 hypothetical protein -
QRF07_RS09070 (QRF07_09070) 1941458..1942168 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T284018 WP_003408465.1 NZ_CP127277:c1937836-1937447 [Mycobacterium tuberculosis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT284018 WP_003408469.1 NZ_CP127277:c1938060-1937833 [Mycobacterium tuberculosis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References