Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
Location | 1685906..1686522 | Replicon | chromosome |
Accession | NZ_CP127277 | ||
Organism | Mycobacterium tuberculosis strain 25421 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | G0TJ74 |
Locus tag | QRF07_RS07950 | Protein ID | WP_003407593.1 |
Coordinates | 1686205..1686522 (+) | Length | 106 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | G0TJ73 |
Locus tag | QRF07_RS07945 | Protein ID | WP_003900349.1 |
Coordinates | 1685906..1686208 (+) | Length | 101 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
QRF07_RS07935 (QRF07_07935) | 1681792..1683639 | + | 1848 | WP_003407585.1 | methylmalonyl-CoA mutase small subunit | - |
QRF07_RS07940 (QRF07_07940) | 1683640..1685892 | + | 2253 | WP_003407587.1 | methylmalonyl-CoA mutase | - |
QRF07_RS07945 (QRF07_07945) | 1685906..1686208 | + | 303 | WP_003900349.1 | type II toxin-antitoxin system antitoxin MazE4 | Antitoxin |
QRF07_RS07950 (QRF07_07950) | 1686205..1686522 | + | 318 | WP_003407593.1 | type II toxin-antitoxin system toxin endoribonuclease MazF4 | Toxin |
QRF07_RS07955 (QRF07_07955) | 1686519..1687523 | + | 1005 | WP_003407596.1 | methylmalonyl Co-A mutase-associated GTPase MeaB | - |
QRF07_RS07960 (QRF07_07960) | 1687576..1688865 | + | 1290 | WP_003902090.1 | serine hydrolase domain-containing protein | - |
QRF07_RS07965 (QRF07_07965) | 1688938..1689663 | - | 726 | WP_003898898.1 | class I SAM-dependent methyltransferase | - |
QRF07_RS07970 (QRF07_07970) | 1689769..1689981 | - | 213 | WP_003898900.1 | dodecin family protein | - |
QRF07_RS07975 (QRF07_07975) | 1690042..1690440 | + | 399 | WP_003900351.1 | hypothetical protein | - |
QRF07_RS07980 (QRF07_07980) | 1690485..1691513 | + | 1029 | WP_003407612.1 | glycosyltransferase family 2 protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 11377.97 Da Isoelectric Point: 7.9950
>T284016 WP_003407593.1 NZ_CP127277:1686205-1686522 [Mycobacterium tuberculosis]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP
Download Length: 318 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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