Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1573747..1574402 Replicon chromosome
Accession NZ_CP127277
Organism Mycobacterium tuberculosis strain 25421

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA6
Locus tag QRF07_RS07450 Protein ID WP_003898861.1
Coordinates 1573747..1574148 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TIK2
Locus tag QRF07_RS07455 Protein ID WP_003407272.1
Coordinates 1574145..1574402 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF07_RS07435 (QRF07_07435) 1569219..1570604 - 1386 WP_003407260.1 cytochrome P450 -
QRF07_RS07440 (QRF07_07440) 1570682..1571716 + 1035 WP_003407264.1 AraC family transcriptional regulator -
QRF07_RS07445 (QRF07_07445) 1571762..1573492 - 1731 WP_009940170.1 PE family protein -
QRF07_RS07450 (QRF07_07450) 1573747..1574148 - 402 WP_003898861.1 type II toxin-antitoxin system VapC family toxin Toxin
QRF07_RS07455 (QRF07_07455) 1574145..1574402 - 258 WP_003407272.1 CopG family transcriptional regulator Antitoxin
QRF07_RS07460 (QRF07_07460) 1574485..1575444 - 960 WP_003407276.1 alpha/beta hydrolase -
QRF07_RS07465 (QRF07_07465) 1575469..1576431 - 963 WP_003905554.1 alpha/beta hydrolase -
QRF07_RS07470 (QRF07_07470) 1576430..1577167 + 738 WP_031647000.1 lysoplasmalogenase -
QRF07_RS07475 (QRF07_07475) 1577248..1579215 + 1968 WP_003407285.1 primosomal protein N' -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14952.43 Da        Isoelectric Point: 11.4656

>T284015 WP_003898861.1 NZ_CP127277:c1574148-1573747 [Mycobacterium tuberculosis]
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQDLQLATLNVWHFPMFEQLKPPFAVPGHRPRA

Download         Length: 402 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9443.58 Da        Isoelectric Point: 6.4631

>AT284015 WP_003407272.1 NZ_CP127277:c1574402-1574145 [Mycobacterium tuberculosis]
MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQV
WRATS

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045ISB0

Antitoxin

Source ID Structure
AlphaFold DB G0TIK2

References