Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel-ATphRel/-
Location 1538025..1539075 Replicon chromosome
Accession NZ_CP127277
Organism Mycobacterium tuberculosis strain 25421

Toxin (Protein)


Gene name phRel Uniprot ID G0TIH2
Locus tag QRF07_RS07295 Protein ID WP_003407164.1
Coordinates 1538025..1538846 (+) Length 274 a.a.

Antitoxin (Protein)


Gene name ATphRel Uniprot ID A0A7U4BTV8
Locus tag QRF07_RS07300 Protein ID WP_003407167.1
Coordinates 1538839..1539075 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF07_RS07275 (QRF07_07275) 1533583..1534245 - 663 WP_003407152.1 membrane protein -
QRF07_RS07280 (QRF07_07280) 1534242..1535027 - 786 WP_003407157.1 membrane protein -
QRF07_RS07285 (QRF07_07285) 1535318..1537279 - 1962 WP_003407159.1 sigma-F factor regulator -
QRF07_RS07290 (QRF07_07290) 1537418..1537804 - 387 WP_003898845.1 anti-sigma-F factor antagonist RsfA -
QRF07_RS07295 (QRF07_07295) 1538025..1538846 + 822 WP_003407164.1 GTP pyrophosphokinase family protein Toxin
QRF07_RS07300 (QRF07_07300) 1538839..1539075 + 237 WP_003407167.1 hypothetical protein Antitoxin
QRF07_RS07305 (QRF07_07305) 1539147..1540352 - 1206 WP_003918234.1 serine hydrolase domain-containing protein -
QRF07_RS07310 (QRF07_07310) 1540655..1541440 + 786 WP_003902048.1 lipoprotein LprF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(76-174)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 274 a.a.        Molecular weight: 30100.10 Da        Isoelectric Point: 5.8187

>T284014 WP_003407164.1 NZ_CP127277:1538025-1538846 [Mycobacterium tuberculosis]
VVVALVGSAIVDLHSRPPWSNNAVRRLGVALRDGVDPPVDCPSYAEVMLWHADLAAEVQDRIEGRSWSASELLVTSRAKS
QDTLLAKLRRRPYLQLNTIQDIAGVRIDADLLLGEQTRLAREIADHFGADQPAIHDLRDHPHAGYRAVHVWLRLPAGRVE
IQIRTILQSLWANFYELLADAYGRGIRYDERPEQLAAGVVPAQLQELVGVMQDASADLAMHEAEWQHCAEIEYPGQRAMA
LGEASKNKATVLATTKFRLERAINEAESAGGGG

Download         Length: 822 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8830.90 Da        Isoelectric Point: 7.3178

>AT284014 WP_003407167.1 NZ_CP127277:1538839-1539075 [Mycobacterium tuberculosis]
VGEVAGYVVEYNRRTHVRRITEFATPQEAMEHRLKLEAERTDSNIEIVALVSKSLGTLKQTHSRYFTGEELNVGNGAR

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIH2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BTV8

References