Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1383915..1384603 Replicon chromosome
Accession NZ_CP127277
Organism Mycobacterium tuberculosis strain 25421

Toxin (Protein)


Gene name vapC Uniprot ID G0THR7
Locus tag QRF07_RS06620 Protein ID WP_003406304.1
Coordinates 1384172..1384603 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0THR6
Locus tag QRF07_RS06615 Protein ID WP_003406302.1
Coordinates 1383915..1384175 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF07_RS06595 (QRF07_06595) 1379492..1380316 + 825 WP_003900298.1 trehalose ABC transporter permease SugB -
QRF07_RS06600 (QRF07_06600) 1380321..1381502 + 1182 WP_003406299.1 trehalose ABC transporter ATP-binding protein SugC -
QRF07_RS06605 (QRF07_06605) 1381579..1382679 - 1101 WP_003406300.1 magnesium/cobalt transporter CorA -
QRF07_RS06610 (QRF07_06610) 1382850..1383839 + 990 WP_003406301.1 malate dehydrogenase -
QRF07_RS06615 (QRF07_06615) 1383915..1384175 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 Antitoxin
QRF07_RS06620 (QRF07_06620) 1384172..1384603 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin Toxin
QRF07_RS06625 (QRF07_06625) 1384626..1386314 - 1689 WP_286027218.1 PE family protein -
QRF07_RS06630 (QRF07_06630) 1386494..1387354 + 861 WP_003900301.1 glycine betaine ABC transporter substrate-binding protein -
QRF07_RS06635 (QRF07_06635) 1387435..1388265 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
QRF07_RS06640 (QRF07_06640) 1388322..1388615 - 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE -
QRF07_RS06645 (QRF07_06645) 1388612..1388881 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(2-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15873.08 Da        Isoelectric Point: 5.8838

>T284012 WP_003406304.1 NZ_CP127277:1384172-1384603 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Download         Length: 432 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9918.25 Da        Isoelectric Point: 6.4755

>AT284012 WP_003406302.1 NZ_CP127277:1383915-1384175 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0THR7

Antitoxin

Source ID Structure
AlphaFold DB G0THR6

References