Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
Location | 1023848..1024821 | Replicon | chromosome |
Accession | NZ_CP127277 | ||
Organism | Mycobacterium tuberculosis strain 25421 |
Toxin (Protein)
Gene name | tacT | Uniprot ID | O05911 |
Locus tag | QRF07_RS04875 | Protein ID | WP_003404756.1 |
Coordinates | 1024321..1024821 (+) | Length | 167 a.a. |
Antitoxin (Protein)
Gene name | tacA | Uniprot ID | - |
Locus tag | QRF07_RS04870 | Protein ID | WP_031653527.1 |
Coordinates | 1023848..1024324 (+) | Length | 159 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
QRF07_RS04850 (QRF07_04850) | 1019695..1020966 | - | 1272 | WP_016330387.1 | PPE family protein | - |
QRF07_RS04855 (QRF07_04855) | 1020981..1021280 | - | 300 | WP_003404748.1 | PE family protein | - |
QRF07_RS04860 (QRF07_04860) | 1021724..1023505 | + | 1782 | WP_003404749.1 | BCCT family transporter | - |
QRF07_RS04865 (QRF07_04865) | 1023505..1023759 | + | 255 | WP_003898646.1 | hypothetical protein | - |
QRF07_RS04870 (QRF07_04870) | 1023848..1024324 | + | 477 | WP_031653527.1 | DUF1778 domain-containing protein | Antitoxin |
QRF07_RS04875 (QRF07_04875) | 1024321..1024821 | + | 501 | WP_003404756.1 | GNAT family N-acetyltransferase | Toxin |
QRF07_RS04885 (QRF07_04885) | 1025134..1026453 | - | 1320 | WP_003404757.1 | IS256-like element IS1554 family transposase | - |
QRF07_RS04890 (QRF07_04890) | 1026741..1027322 | + | 582 | WP_003404760.1 | IS607-like element IS1535 family transposase | - |
QRF07_RS04895 (QRF07_04895) | 1027322..1028974 | + | 1653 | WP_003905412.1 | IS607 family element RNA-guided endonuclease TnpB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 167 a.a. Molecular weight: 18048.55 Da Isoelectric Point: 7.8659
>T284008 WP_003404756.1 NZ_CP127277:1024321-1024821 [Mycobacterium tuberculosis]
VSGYSAPRRISDADDVTSFSSGEPSLDDYLRKRALANHVQGGSRCFVTCRDGRVVGFYALASGSVAHADAPGRVRRNMPD
PVPVILLSRLAVDRKEQGRGLGSHLLRDAIGRCVQAADSIGLRAILVHALHDEARAFYVHFDFEISPTDPLHLMLLMKDA
RALIGD
VSGYSAPRRISDADDVTSFSSGEPSLDDYLRKRALANHVQGGSRCFVTCRDGRVVGFYALASGSVAHADAPGRVRRNMPD
PVPVILLSRLAVDRKEQGRGLGSHLLRDAIGRCVQAADSIGLRAILVHALHDEARAFYVHFDFEISPTDPLHLMLLMKDA
RALIGD
Download Length: 501 bp
Antitoxin
Download Length: 159 a.a. Molecular weight: 17383.99 Da Isoelectric Point: 11.0138
>AT284008 WP_031653527.1 NZ_CP127277:1023848-1024324 [Mycobacterium tuberculosis]
MHRAGAAVTANVWCRAGGIRMAPRPVIPVATQQRLRRQADRQSLGGSGLPALNCTPIRYTIDVMATKPERKTERLAARLT
PEQDALIRRAAEAEGTDLTNFTVTAALAHARDVLADRRLFVLTDAAWTEFLAALDRPVSHKPRLEKLFAARSIFDTEG
MHRAGAAVTANVWCRAGGIRMAPRPVIPVATQQRLRRQADRQSLGGSGLPALNCTPIRYTIDVMATKPERKTERLAARLT
PEQDALIRRAAEAEGTDLTNFTVTAALAHARDVLADRRLFVLTDAAWTEFLAALDRPVSHKPRLEKLFAARSIFDTEG
Download Length: 477 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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