Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1023848..1024821 Replicon chromosome
Accession NZ_CP127277
Organism Mycobacterium tuberculosis strain 25421

Toxin (Protein)


Gene name tacT Uniprot ID O05911
Locus tag QRF07_RS04875 Protein ID WP_003404756.1
Coordinates 1024321..1024821 (+) Length 167 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag QRF07_RS04870 Protein ID WP_031653527.1
Coordinates 1023848..1024324 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF07_RS04850 (QRF07_04850) 1019695..1020966 - 1272 WP_016330387.1 PPE family protein -
QRF07_RS04855 (QRF07_04855) 1020981..1021280 - 300 WP_003404748.1 PE family protein -
QRF07_RS04860 (QRF07_04860) 1021724..1023505 + 1782 WP_003404749.1 BCCT family transporter -
QRF07_RS04865 (QRF07_04865) 1023505..1023759 + 255 WP_003898646.1 hypothetical protein -
QRF07_RS04870 (QRF07_04870) 1023848..1024324 + 477 WP_031653527.1 DUF1778 domain-containing protein Antitoxin
QRF07_RS04875 (QRF07_04875) 1024321..1024821 + 501 WP_003404756.1 GNAT family N-acetyltransferase Toxin
QRF07_RS04885 (QRF07_04885) 1025134..1026453 - 1320 WP_003404757.1 IS256-like element IS1554 family transposase -
QRF07_RS04890 (QRF07_04890) 1026741..1027322 + 582 WP_003404760.1 IS607-like element IS1535 family transposase -
QRF07_RS04895 (QRF07_04895) 1027322..1028974 + 1653 WP_003905412.1 IS607 family element RNA-guided endonuclease TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(38-143)

Antitoxin

Vibrio phage ICP1, Orf50

(74-150)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 18048.55 Da        Isoelectric Point: 7.8659

>T284008 WP_003404756.1 NZ_CP127277:1024321-1024821 [Mycobacterium tuberculosis]
VSGYSAPRRISDADDVTSFSSGEPSLDDYLRKRALANHVQGGSRCFVTCRDGRVVGFYALASGSVAHADAPGRVRRNMPD
PVPVILLSRLAVDRKEQGRGLGSHLLRDAIGRCVQAADSIGLRAILVHALHDEARAFYVHFDFEISPTDPLHLMLLMKDA
RALIGD

Download         Length: 501 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 17383.99 Da        Isoelectric Point: 11.0138

>AT284008 WP_031653527.1 NZ_CP127277:1023848-1024324 [Mycobacterium tuberculosis]
MHRAGAAVTANVWCRAGGIRMAPRPVIPVATQQRLRRQADRQSLGGSGLPALNCTPIRYTIDVMATKPERKTERLAARLT
PEQDALIRRAAEAEGTDLTNFTVTAALAHARDVLADRRLFVLTDAAWTEFLAALDRPVSHKPRLEKLFAARSIFDTEG

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSZ2

Antitoxin

Source ID Structure

References