Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 1014318..1014937 Replicon chromosome
Accession NZ_CP127277
Organism Mycobacterium tuberculosis strain 25421

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag QRF07_RS04820 Protein ID WP_003404726.1
Coordinates 1014503..1014937 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ06
Locus tag QRF07_RS04815 Protein ID WP_003898641.1
Coordinates 1014318..1014497 (+) Length 60 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF07_RS04800 (QRF07_04800) 1009792..1011371 + 1580 Protein_946 serine hydrolase -
QRF07_RS04805 (QRF07_04805) 1011368..1013761 + 2394 WP_003898639.1 cation-translocating P-type ATPase -
QRF07_RS04810 (QRF07_04810) 1014034..1014192 + 159 WP_003404720.1 hypothetical protein -
QRF07_RS04815 (QRF07_04815) 1014318..1014497 + 180 WP_003898641.1 antitoxin Antitoxin
QRF07_RS04820 (QRF07_04820) 1014503..1014937 + 435 WP_003404726.1 SRPBCC family protein Toxin
QRF07_RS04825 (QRF07_04825) 1015035..1015808 + 774 WP_003404735.1 VOC family protein -
QRF07_RS04830 (QRF07_04830) 1015873..1016322 + 450 WP_003404738.1 hypothetical protein -
QRF07_RS04835 (QRF07_04835) 1016457..1016687 - 231 WP_003898642.1 hypothetical protein -
QRF07_RS04840 (QRF07_04840) 1016854..1018362 - 1509 WP_003404742.1 carotenoid oxygenase family protein -
QRF07_RS04845 (QRF07_04845) 1018364..1019602 - 1239 WP_003404744.1 acetyl-CoA acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15754.47 Da        Isoelectric Point: 9.7977

>T284007 WP_003404726.1 NZ_CP127277:1014503-1014937 [Mycobacterium tuberculosis]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Download         Length: 435 bp

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6403.07 Da        Isoelectric Point: 4.5393

>AT284007 WP_003898641.1 NZ_CP127277:1014318-1014497 [Mycobacterium tuberculosis]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLHDAASNVVGMSDQQS

Download         Length: 180 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A045KDK5

References