Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 840584..841293 Replicon chromosome
Accession NZ_CP127277
Organism Mycobacterium tuberculosis strain 25421

Toxin (Protein)


Gene name vapC Uniprot ID P9WF74
Locus tag QRF07_RS03975 Protein ID WP_003403837.1
Coordinates 840865..841293 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TEX4
Locus tag QRF07_RS03970 Protein ID WP_003403834.1
Coordinates 840584..840841 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF07_RS03965 (QRF07_03965) 838088..840493 + 2406 WP_286027215.1 PE family protein -
QRF07_RS03970 (QRF07_03970) 840584..840841 + 258 WP_003403834.1 ribbon-helix-helix protein, CopG family Antitoxin
QRF07_RS03975 (QRF07_03975) 840865..841293 + 429 WP_003403837.1 type II toxin-antitoxin system VapC family toxin Toxin
QRF07_RS03980 (QRF07_03980) 841374..841511 - 138 WP_003403839.1 hypothetical protein -
QRF07_RS03985 (QRF07_03985) 841670..841915 + 246 WP_003403841.1 hypothetical protein -
QRF07_RS03990 (QRF07_03990) 841984..842868 - 885 WP_003403844.1 3-hydroxyisobutyrate dehydrogenase -
QRF07_RS03995 (QRF07_03995) 842879..844051 - 1173 WP_003403845.1 acyl-CoA dehydrogenase family protein -
QRF07_RS04000 (QRF07_04000) 844058..845590 - 1533 WP_003403847.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-36)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15831.27 Da        Isoelectric Point: 7.5536

>T284006 WP_003403837.1 NZ_CP127277:840865-841293 [Mycobacterium tuberculosis]
MFLLDANVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVWASFLRLATNRRIFEIPSPRAEAFAFVEAVTAQPHHL
PTNPGPRHLMLLRKLCDEADASGDLIPDAVLAAIAVGHHCAVVSLDRDFARFASVRHIRPPL

Download         Length: 429 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9114.28 Da        Isoelectric Point: 10.6530

>AT284006 WP_003403834.1 NZ_CP127277:840584-840841 [Mycobacterium tuberculosis]
MRTTVSISDEILAAAKRRARERGQSLGAVIEDALRREFAAAHVGGARPTVPVFDGGTGPRRGIDLTSNRALSEVLDEGLE
LNSRK

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CDR3

Antitoxin

Source ID Structure
AlphaFold DB G0TEX4

References