Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-mazE/PIN(toxin)
Location 754617..755409 Replicon chromosome
Accession NZ_CP127277
Organism Mycobacterium tuberculosis strain 25421

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag QRF07_RS03495 Protein ID WP_003403386.1
Coordinates 754972..755409 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TQE0
Locus tag QRF07_RS03490 Protein ID WP_003403381.1
Coordinates 754617..754862 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF07_RS03460 (QRF07_03460) 749637..751142 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
QRF07_RS03465 (QRF07_03465) 751223..752233 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
QRF07_RS03470 (QRF07_03470) 752621..753004 - 384 WP_003403365.1 ribonuclease VapC6 -
QRF07_RS03475 (QRF07_03475) 753099..753254 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
QRF07_RS03480 (QRF07_03480) 753330..754046 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
QRF07_RS03485 (QRF07_03485) 754322..754630 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
QRF07_RS03490 (QRF07_03490) 754617..754862 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family Antitoxin
QRF07_RS03495 (QRF07_03495) 754972..755409 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
QRF07_RS03500 (QRF07_03500) 755406..755660 - 255 WP_003911263.1 antitoxin VapB7 -
QRF07_RS03505 (QRF07_03505) 755774..758137 + 2364 WP_003901895.1 arylsulfatase AtsD -
QRF07_RS03510 (QRF07_03510) 758200..758526 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
QRF07_RS03515 (QRF07_03515) 758438..758776 + 339 WP_003403405.1 PIN domain-containing protein -
QRF07_RS03520 (QRF07_03520) 758773..758946 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T284004 WP_003403386.1 NZ_CP127277:c755409-754972 [Mycobacterium tuberculosis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9169.01 Da        Isoelectric Point: 4.2070

>AT284004 WP_003403381.1 NZ_CP127277:c754862-754617 [Mycobacterium tuberculosis]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB G0TQE0

References