Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 710419..711044 Replicon chromosome
Accession NZ_CP127277
Organism Mycobacterium tuberculosis strain 25421

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag QRF07_RS03250 Protein ID WP_003403218.1
Coordinates 710643..711044 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag QRF07_RS03245 Protein ID WP_003403213.1
Coordinates 710419..710646 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF07_RS03220 (QRF07_03220) 705598..705819 - 222 WP_003898525.1 DUF4926 domain-containing protein -
QRF07_RS03225 (QRF07_03225) 705961..706566 + 606 WP_003898526.1 hypothetical protein -
QRF07_RS03230 (QRF07_03230) 706585..709152 - 2568 WP_003901879.1 SEC-C metal-binding domain-containing protein -
QRF07_RS03235 (QRF07_03235) 709236..709985 + 750 WP_003898528.1 hypothetical protein -
QRF07_RS03240 (QRF07_03240) 709982..710224 + 243 WP_003403210.1 hypothetical protein -
QRF07_RS03245 (QRF07_03245) 710419..710646 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
QRF07_RS03250 (QRF07_03250) 710643..711044 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
QRF07_RS03255 (QRF07_03255) 711173..711256 + 84 Protein_645 galactose-1-phosphate uridylyltransferase -
QRF07_RS03260 (QRF07_03260) 711275..712356 + 1082 Protein_646 galactose-1-phosphate uridylyltransferase -
QRF07_RS03265 (QRF07_03265) 712353..713444 + 1092 WP_003900977.1 galactokinase -
QRF07_RS03270 (QRF07_03270) 713839..714903 + 1065 WP_003898532.1 zinc ribbon domain-containing protein -
QRF07_RS03275 (QRF07_03275) 715007..715954 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T283999 WP_003403218.1 NZ_CP127277:710643-711044 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT283999 WP_003403213.1 NZ_CP127277:710419-710646 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References