Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 702881..703524 Replicon chromosome
Accession NZ_CP127277
Organism Mycobacterium tuberculosis strain 25421

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag QRF07_RS03200 Protein ID WP_003403187.1
Coordinates 703123..703524 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag QRF07_RS03195 Protein ID WP_003403184.1
Coordinates 702881..703126 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF07_RS03160 (QRF07_03160) 698161..698691 - 531 WP_003917320.1 two component system sensor kinase HK2 -
QRF07_RS03165 (QRF07_03165) 698675..699370 - 696 WP_003918099.1 two-component system response regulator TcrA -
QRF07_RS03170 (QRF07_03170) 699493..699804 + 312 WP_003403164.1 hypothetical protein -
QRF07_RS03175 (QRF07_03175) 699876..700826 + 951 WP_003900184.1 DUF1259 domain-containing protein -
QRF07_RS03180 (QRF07_03180) 701067..701651 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
QRF07_RS03185 (QRF07_03185) 701653..702363 + 711 Protein_631 IS607 family element RNA-guided endonuclease TnpB -
QRF07_RS03190 (QRF07_03190) 702366..702836 + 471 WP_003898523.1 hypothetical protein -
QRF07_RS03195 (QRF07_03195) 702881..703126 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QRF07_RS03200 (QRF07_03200) 703123..703524 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
QRF07_RS03205 (QRF07_03205) 703515..703694 + 180 Protein_635 hypothetical protein -
QRF07_RS03210 (QRF07_03210) 704112..704309 - 198 WP_003403191.1 hypothetical protein -
QRF07_RS03215 (QRF07_03215) 704389..705546 - 1158 WP_003898524.1 hypothetical protein -
QRF07_RS03220 (QRF07_03220) 705598..705819 - 222 WP_003898525.1 DUF4926 domain-containing protein -
QRF07_RS03225 (QRF07_03225) 705961..706566 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T283998 WP_003403187.1 NZ_CP127277:703123-703524 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT283998 WP_003403184.1 NZ_CP127277:702881-703126 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References