Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-CcdA
Location 639865..640541 Replicon chromosome
Accession NZ_CP127277
Organism Mycobacterium tuberculosis strain 25421

Toxin (Protein)


Gene name vapC Uniprot ID G0TPQ9
Locus tag QRF07_RS02895 Protein ID WP_003898500.1
Coordinates 639865..640278 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TPR0
Locus tag QRF07_RS02900 Protein ID WP_003402915.1
Coordinates 640275..640541 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF07_RS02865 (QRF07_02865) 635210..635512 - 303 WP_003402896.1 DUF3349 domain-containing protein -
QRF07_RS02870 (QRF07_02870) 635572..635850 - 279 WP_003402901.1 hypothetical protein -
QRF07_RS02875 (QRF07_02875) 635847..637100 - 1254 WP_003402904.1 inorganic phosphate transporter -
QRF07_RS02880 (QRF07_02880) 637220..637606 - 387 WP_003402907.1 VOC family protein -
QRF07_RS02885 (QRF07_02885) 637669..638553 - 885 WP_003402909.1 SDR family oxidoreductase -
QRF07_RS02890 (QRF07_02890) 638649..639551 - 903 WP_003915439.1 1,4-dihydroxy-2-naphthoyl-CoA synthase -
QRF07_RS02895 (QRF07_02895) 639865..640278 - 414 WP_003898500.1 type II toxin-antitoxin system VapC family toxin Toxin
QRF07_RS02900 (QRF07_02900) 640275..640541 - 267 WP_003402915.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
QRF07_RS02905 (QRF07_02905) 640733..642448 - 1716 WP_003402917.1 fatty-acid--CoA ligase FadD8 -
QRF07_RS02910 (QRF07_02910) 642526..644130 + 1605 WP_003402920.1 amidohydrolase -
QRF07_RS02915 (QRF07_02915) 644127..645107 + 981 WP_003402923.1 o-succinylbenzoate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(13-129)

Antitoxin

Post-segregation antitoxin CcdA

(19-61)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14667.78 Da        Isoelectric Point: 7.3603

>T283994 WP_003898500.1 NZ_CP127277:c640278-639865 [Mycobacterium tuberculosis]
VRASPTSPPEQVVVDASAMVDLLARTSDRCSAVRARLARTAMHAPAHFDAEVLSALGRMQRAGALTVAYVDAALEELRQV
PVTRHGLSSLLAGAWSRRDTLRLTDALYVELAETAGLVLLTTDERLARAWPSAHAIG

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9543.79 Da        Isoelectric Point: 4.5994

>AT283994 WP_003402915.1 NZ_CP127277:c640541-640275 [Mycobacterium tuberculosis]
MLSRRTKTIVVCTLVCMARLNVYVPDELAERARARGLNVSALTQAAISAELENSATDAWLEGLEPRSTGARHDDVLGAID
AARDEFEA

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPQ9

Antitoxin

Source ID Structure
AlphaFold DB G0TPR0

References